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Please note that the physiological activity of the ingredient(s) described herein is supported by the referenced clinical trial reports. Marketers of finished products containing the ingredient(s) described herein are responsible for determining whether claims made for such products are lawful and in compliance with the laws of the country in which they will market the products.



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Pomegranate (Punica granatum) extract and its polyphenols reduce the formation of methylglyoxal-DNA adducts and protect human keratinocytes against methylglyoxal-induced oxidative stress.

Guo H et al.
J Funct Foods. Aug 2021. 83: 104564. doi: 10.1016/j.jff.2021.104564
Pomegranate extract (PE) and its polyphenols have been reported to show skin protective effects but their cytoprotective effects against methylglyoxal (MGO)-induced DNA damage and cell dysfunctions are unclear. Herein, we evaluated whether PE, punicalagin (PA), ellagic acid (EA), and urolithin A (UA), can alleviate MGO-induced DNA damage in human keratinocytes. PE (50 µg/mL) and PA (50 µM) protected DNA integrity and reduced the formation of MGO-DNA adducts and tailed DNA by 60.2 and 49.7%, respectively, in HaCaT cells.

Screening of Punica granatum extract for antimicrobial activity against oral micro organisms.

Avadhani M et al.
J Ayurvedic Herbal Med. 2020. 6(2): 73-77.

Hepatoprotective and anti-inflammatory effects of a standardized pomegranate (Punica granatum) fruit extract in high fat diet-induced obese C57BL/6 mice.

Pfohl M et al.
Inter J Food Sci Nut. 2020. 1-12.

Ellagic acid source identification by UFLC-PDA-ESI-MS/MS.

Girme A et al.
2019 Oct. Poster presentation in 8th Annual AHPA Botanical Congress.
Development of methodology for analysis of ellagic acid before and after hydrolysis from its prominent source, i.e. Punica granatum. This method has application in confirmation and identification of ellagic acid source identification for confirmation dietary supplement label/s meet stated claim/s for pomegranate extract content.

Biological evaluations of skin protective effects of Pomella® extract on type-I collagen, DNA structure integrity, and human keratinocytes against oxidative and glycative stress.

Ma H et al.
2019 May. Poster presentation in Vitafoods Europe. Geneva, Switzerland.
Pomella® and its phenolics showed protective effects on type-I collagen, DNA structure integrity, and human keratinocytes against H2O2- and MGO-induced oxidative and glycative stress. Punicalagin showed the most promising biological activities among tested pomegranate phenolics. The results suggest that pomegranate phenolics may be utilized as natural antioxidants for various cosmeceutical applications including consumable and topical products for skin health.

Pomegranate phenolics inhibit type I collagen cross-linking induced by glycative stress.

Cai A et al.
FASEB J. 2018 Apr. 32(1): 656.35.
Three of the pomegranate phenolics that Pomella® includes (punicalagin, ellagic acid, and urolithin A) were examined to determine the protective effects on collagen glycation. It was found that the phenolics inhibited fructose-induced collagen glycation by as much as 64.4%, exhibited protective effects on the secondary structure of collagen (when exposed to the denaturing effect of glycation), and inhibited the formation of Amadori products by as much as 45.7%.

Pomegranate (Punica granatum) phenolics ameliorate hydrogen peroxide-induced oxidative stress and cytotoxicity in human keratinocytes.

Liu C et al.
J Funct Foods. 2019. 54: 559-567. doi: 10.1016/j.jff.2019.02.015
Pomella® and its phenolics (punicalagin, ellagic acid, and urolithin A) were investigated in the reduction of oxidative stress and cytotoxicity in keratinocytes and found that the substances reduced the production of hydrogen peroxide induced ROS, increased the viability of the cells, and reduced apoptotic cell populations. This study points to Pomella having potential applications as a natural cosmeceutical for skin health.

Antiproliferative activities of ashwagandha, turmeric, Pomella®, sesamin, and cinnamon extracts against colon and breast cells.