These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

Please note that the physiological activity of the ingredient(s) described herein is supported by the referenced clinical trial reports. Marketers of finished products containing the ingredient(s) described herein are responsible for determining whether claims made for such products are lawful and in compliance with the laws of the country in which they will market the products.



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Pomegranate (Punica granatum) extract and its polyphenols reduce the formation of methylglyoxal-DNA adducts and protect human keratinocytes against methylglyoxal-induced oxidative stress.

Guo H et al.
J Funct Foods. Aug 2021. 83: 104564. doi: 10.1016/j.jff.2021.104564
Pomegranate extract (PE) and its polyphenols have been reported to show skin protective effects but their cytoprotective effects against methylglyoxal (MGO)-induced DNA damage and cell dysfunctions are unclear. Herein, we evaluated whether PE, punicalagin (PA), ellagic acid (EA), and urolithin A (UA), can alleviate MGO-induced DNA damage in human keratinocytes. PE (50 µg/mL) and PA (50 µM) protected DNA integrity and reduced the formation of MGO-DNA adducts and tailed DNA by 60.2 and 49.7%, respectively, in HaCaT cells.

Screening of Punica granatum extract for antimicrobial activity against oral micro organisms.

Avadhani M et al.
J Ayurvedic Herbal Med. 2020. 6(2): 73-77.

Hepatoprotective and anti-inflammatory effects of a standardized pomegranate (Punica granatum) fruit extract in high fat diet-induced obese C57BL/6 mice.

Pfohl M et al.
Inter J Food Sci Nut. 2020. 1-12.

Ellagic acid source identification by UFLC-PDA-ESI-MS/MS.

Girme A et al.
2019 Oct. Poster presentation in 8th Annual AHPA Botanical Congress.
Development of methodology for analysis of ellagic acid before and after hydrolysis from its prominent source, i.e. Punica granatum. This method has application in confirmation and identification of ellagic acid source identification for confirmation dietary supplement label/s meet stated claim/s for pomegranate extract content.

Biological evaluations of skin protective effects of Pomella® extract on type-I collagen, DNA structure integrity, and human keratinocytes against oxidative and glycative stress.

Ma H et al.
2019 May. Poster presentation in Vitafoods Europe. Geneva, Switzerland.
Pomella® and its phenolics showed protective effects on type-I collagen, DNA structure integrity, and human keratinocytes against H2O2- and MGO-induced oxidative and glycative stress. Punicalagin showed the most promising biological activities among tested pomegranate phenolics. The results suggest that pomegranate phenolics may be utilized as natural antioxidants for various cosmeceutical applications including consumable and topical products for skin health.

Pomegranate phenolics inhibit type I collagen cross-linking induced by glycative stress.

Cai A et al.
FASEB J. 2018 Apr. 32(1): 656.35.
Three of the pomegranate phenolics that Pomella® includes (punicalagin, ellagic acid, and urolithin A) were examined to determine the protective effects on collagen glycation. It was found that the phenolics inhibited fructose-induced collagen glycation by as much as 64.4%, exhibited protective effects on the secondary structure of collagen (when exposed to the denaturing effect of glycation), and inhibited the formation of Amadori products by as much as 45.7%.

Pomegranate (Punica granatum) phenolics ameliorate hydrogen peroxide-induced oxidative stress and cytotoxicity in human keratinocytes.

Liu C et al.
J Funct Foods. 2019. 54: 559-567. doi: 10.1016/j.jff.2019.02.015
Pomella® and its phenolics (punicalagin, ellagic acid, and urolithin A) were investigated in the reduction of oxidative stress and cytotoxicity in keratinocytes and found that the substances reduced the production of hydrogen peroxide induced ROS, increased the viability of the cells, and reduced apoptotic cell populations. This study points to Pomella having potential applications as a natural cosmeceutical for skin health.

Antiproliferative activities of ashwagandha, turmeric, Pomella®, sesamin, and cinnamon extracts against colon and breast cells.

Parang K & Nasrolahi Shirazi A.
Poster presentation in Southern California Conferences for Undergraduate Research. 2019. Poster 4, Location 180.

Liquid chromatography coupled with time-of-flight tandem mass spectrometry for comprehensive phenolic characterization of pomegranate fruit and flower extracts used as ingredients in botanical dietary supplements.

Liu Y et al.
J Sep Sci. 2018 May 30. Vol 41(Issue 15 - August 2018): 3022-3033. doi: 10.1002/jssc.201800480
Pomella® phenolics are comprehensively characterized by a validated liquid chromatography with time-of -flight tandem mass spectrometry method in the highly regarded journal, Journal of Separation Science. This study aids in quality control, authentication of study materials, and standardization of these botanical ingredients to help evaluate their potential health benefits in both completed and on-going pre-clinical and clinical studies.

Antioxidative effect of Punica granatum (pomegranate) on biochemical parameters in patients with T2D and MI: A double blind placebo controlled trial.

Goyal R et al.
Int J Adv Res. 2016 May. Vol 4(Issue 5): 857-864. doi: 10.21474/IJAR01
Patients were administered 300mg of Pomella® twice daily for 30-days as an adjunct treatment and showed significant improvements in key metabolic biomarkers. Especially significant decreases in blood glucose and HbA1c were seen compared to baseline.

An antioxidative effect of Punica granatum (pomegranate) on biochemical parameters in patients with MI: A double blind placebo controlled trial.

Goyal R et al.
Eur J Biomed Pharma Sci. 2016 Apr 30. Vol 3(Issue 5): 662-667.
Patients were administered 300mg of Pomella® twice daily for 30-days as an adjunct treatment and showed significant improvements in biomedical parameters such as HDL, OX-LDL, serum homocysteine, hs-CRP, and others.

Pomegranate’s neuroprotective effects are mediated by urolithins, its ellagitannin-gut microbial derived metabolites.

Yuan T et al.
ACS Chem Neurosci. 2015 Nov 11. doi: 10.1021/acschemneuro.5b00260
Urolithins, gut microbial metabolites of ellagitannins, fulfilled in silico criteria required for BBB permeability, and prevented β-amyloid fibrillation in vivo. Moreover, urolithins not only prevented β-amyloid fibrillation in vitro, they also protected Caenorhabditis elegans from amyloid β1−42 induced neurotoxicity and paralysis, supporting Pomella's neuroprotective effect.

Evaluation of bioactivity of pomegranate fruit extract against Alicyclobacillus acidoterrestris DSM 3922 vegetative cells and spores in apple juice.