Pomegranate’s neuroprotective effects are mediated by urolithins, its ellagitannin-gut microbial derived metabolites.
Yuan T et al.
ACS Chem Neurosci. 2015 Nov 11. doi: 10.1021/acschemneuro.5b00260
Urolithins, gut microbial metabolites of ellagitannins, fulfilled in silico criteria required for BBB permeability, and prevented β-amyloid fibrillation in vivo. Moreover, urolithins not only prevented β-amyloid fibrillation in vitro, they also protected Caenorhabditis elegans from amyloid β1−42 induced neurotoxicity and paralysis, supporting Pomella's neuroprotective effect.