Pomella®
Research

These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

Please note that the physiological activity of the ingredient(s) described herein is supported by the referenced clinical trial reports. Marketers of finished products containing the ingredient(s) described herein are responsible for determining whether claims made for such products are lawful and in compliance with the laws of the country in which they will market the products.

Pomella®
Research

Pomella®
Research

Don’t see what you’re looking for? All additional research is categorized under supportive research.

  • Filter By Category:

  • Filter By Dosage:

Protective effects of standardized pomegranate (Punica granatum L) polyphenolic extract in ultraviolet-irradiated human skin fibroblasts.

Pacheco-Palencia LA et al.
J Agric Food Chem. 2008 Jul 18. EPub 2008 Aug 22. doi: 10.1021/jf8005307
Pomella® was shown to be effective at protecting human skin fibroblasts from cell death following UVA and UVB exposure, while increasing the intracellular antioxidant capacity, and reducing the generation of intracellular reactive oxygen species (ROS) after UV exposure.
View Full Study

Safety assessment of pomegranate fruit extract: Acute and subchronic toxicity studies.

Patel C et al.
2008 Apr 24. 46: 2728-2735. doi: 10.1016/j.fct.2008.04.035
Results of this trial indicated that the no observed adverse effect level (NOAEL) at the highest tested level of Pomella®, was 600 mg/kg body weight/day.
View Full Study

Comparison of antioxidant potency of commonly consumed polyphenol-rich beverages in the United States.

Seeram NP et al.
J Agric Food Chem. 2008 Feb 27. 56(4): 1415-1422. EPub 2008 Jan 26. doi: 10.1021/jf073035s
Pomegranate juice was shown to have the greatest antioxidant potential of all the beverages tested in this study. Specifically, and notably, it beat out red wine, grape juice, blueberry juice, black cherry juice, açai juice, cranberry juice, and apple juice.

Pomegranate juice extracts provide similar levels of plasma and urinary ellagitannin metabolites in human subjects.

Seeram NP et al.
J Med Food. 2008 Jan 23. 11(2): 390-394. doi: 10.1089/jmf.2007.650
Pomegranate extract was found to deliver equivalent levels of ellagitannin metabolites when compared to pomegranate juice and liquid pomegranate liquid extract.

Macrophage paraoxonase 2 (PON2) expression is up-regulated by pomegranate juice phenolic antioxidants via PPAR gamma and AP-1 pathway activation.

Shiner M et al.
Atherosclerosis. 2007 Dec. 195(2): 313-321. EPub 2007 Feb 12. doi: 10.1016/j.atherosclerosis.2007.01.007
Macrophages were incubated in pomegranate juice in increasing doses in an effort to determine the mechanism of action that pomegranate polyphenols have on oxidative stress. It was shown that the anti-oxidative characteristics of pomegranate polyphenol could be explained at least in part to their stimulatory effect on macrophage PON2 expression, which was shown to be associated with activation of transcription factors PPAR gamma and AP-1.

Safety and antioxidant activity of a pomeganate ellagitannin-enriched polyphenol dietary supplement in overweight individuals with increased waist size.

Heber D et al.
J Agric Food Chem. 2007 Nov 28. 55(24): 10050-10054. EPub 2007 Oct 30.
A pomegranate ellagitannin-enriched polyphenol extract was prepared and administered to overweight individuals in two studies. Study 1 was designed for safety assessment, and study 2 for antioxidant assessment. It was observed that there were no serious adverse events in any subjects in either study, and there was evidence of antioxidant activity “through a significant reduction in TBARS linked with cardiovascular disease risk.”

The influence of pomegranate fruit extract in comparison to regular pomegranate juice and seed oil on nitric oxide and arterial function in obese Zucker rats.

deNigris F et al.
Nitric Oxide. 2007 Aug. 17(1): 50-54. EPub 2007 May 5. doi: 10.1016/j.niox.2007.04.005
Pomegranate fruit extract was shown to decrease the expression of vascular inflammation markers and increase plasma nitrate and nitrite levels in effects comparable to pomegranate juice in obese Zucker rats.

Effects of a pomegranate fruit extract rich in punicalagin on oxidation-sensitive genes and eNOS activity at sites of perturbed shear stress and atherogenesis.

deNigris F et al.
Cardiovasc Res. 2007 Jan 15. 73(2): 414-423. EPub 2006 Sep 01. doi: 10.1016/j.cardiores.2006.08.021
A pomegranate fruit extract rich in punicalagins was shown to reverse proatherogenic (promotion of fatty plaque build-up in the arteries) effects induced by shear stress through chronic administration.

Pomegranate juice ellagitannin metabolites are present in human plasma and some persist in urine for up to 48 hours.

Seeram NP et al.
J Nutr. 2006 Oct. 136(10): 2481-2485. doi: 10.1093/jn/136.10.2481
Demonstrates the length of time that polyphenols of pomegranate would persist in the human body after consumption.

Absorption, metabolism, and antioxidant effects of pomegranate (Punica granatum L) polyphenols after ingestion of a standardized extract [Pomella®] in healthy human volunteers.

Mertens-Talcott SU et al.
J Agric Food Chem. 2006 Sep 6. 54(23): 8956-8961. EPub 2006 Oct 13. doi: 10.1021/jf061674h
Pomella’s patented extraction process delivers an ellagitannin rich profile standardized to punicalagin content. A single dose of Pomella led to a significant 32% increase of antioxidant activity in the blood. Bioactive punicalagin derived metabolites were detected in half an hour after dosing.
View Full Study

Bioavailability of ellagic acid in human plasma after consumption of ellagitannins from promegranate (Punica granatum L) juice.

Seeram NP et al.
Clinica Chimica Acta. 2004 Apr 30. 348: 63-68. doi: 10.1016/j.cccn.2004.04.029
This study was the first to obtain direct evidence of the absorption of ellagic acids in a human from a food source. Biologically active ellagic acids and ellagitannins have important impacts on human health.

Evaluation of the bioavailability and metabolism in the rat of punicalagin, an antioxidant polyphenol from pomegranate juice.

Cerda B et al.
Eur J Nutr. 2003 Jan. 42(1): 18-28. doi: 10.1007/s/00394-003-0396-4

Pomegranate juice consumption inhibits serum angiotensin converting enzyme activity and reduces systolic blood pressure.

Aviram M et al.
Atherosclerosis. 2001 Sep. 158(1): 195-198. doi: 10.1016/s0021-9150(01)00412-9
Hypertensive patients consumed 50 mL of pomegranate juice (1.5 mmol of total polyphenols) per day for two weeks. A 36% decrement in ACE activity and a 5% reduction in systolic blood pressure were noted; reduction in ACE activity has been shown to attenuate atherosclerosis.
1 2 3

Don’t see what you’re looking for? All additional research is categorized under supportive research.

  • Filter By Category:

  • Filter By Dosage:

Protective effects of standardized pomegranate (Punica granatum L) polyphenolic extract in ultraviolet-irradiated human skin fibroblasts.

Pacheco-Palencia LA et al.
J Agric Food Chem. 2008 Jul 18. EPub 2008 Aug 22. doi: 10.1021/jf8005307
Pomella® was shown to be effective at protecting human skin fibroblasts from cell death following UVA and UVB exposure, while increasing the intracellular antioxidant capacity, and reducing the generation of intracellular reactive oxygen species (ROS) after UV exposure.
View Full Study

Safety assessment of pomegranate fruit extract: Acute and subchronic toxicity studies.

Patel C et al.
2008 Apr 24. 46: 2728-2735. doi: 10.1016/j.fct.2008.04.035
Results of this trial indicated that the no observed adverse effect level (NOAEL) at the highest tested level of Pomella®, was 600 mg/kg body weight/day.
View Full Study

Comparison of antioxidant potency of commonly consumed polyphenol-rich beverages in the United States.

Seeram NP et al.
J Agric Food Chem. 2008 Feb 27. 56(4): 1415-1422. EPub 2008 Jan 26. doi: 10.1021/jf073035s
Pomegranate juice was shown to have the greatest antioxidant potential of all the beverages tested in this study. Specifically, and notably, it beat out red wine, grape juice, blueberry juice, black cherry juice, açai juice, cranberry juice, and apple juice.

Pomegranate juice extracts provide similar levels of plasma and urinary ellagitannin metabolites in human subjects.

Seeram NP et al.
J Med Food. 2008 Jan 23. 11(2): 390-394. doi: 10.1089/jmf.2007.650
Pomegranate extract was found to deliver equivalent levels of ellagitannin metabolites when compared to pomegranate juice and liquid pomegranate liquid extract.

Macrophage paraoxonase 2 (PON2) expression is up-regulated by pomegranate juice phenolic antioxidants via PPAR gamma and AP-1 pathway activation.

Shiner M et al.
Atherosclerosis. 2007 Dec. 195(2): 313-321. EPub 2007 Feb 12. doi: 10.1016/j.atherosclerosis.2007.01.007
Macrophages were incubated in pomegranate juice in increasing doses in an effort to determine the mechanism of action that pomegranate polyphenols have on oxidative stress. It was shown that the anti-oxidative characteristics of pomegranate polyphenol could be explained at least in part to their stimulatory effect on macrophage PON2 expression, which was shown to be associated with activation of transcription factors PPAR gamma and AP-1.

Safety and antioxidant activity of a pomeganate ellagitannin-enriched polyphenol dietary supplement in overweight individuals with increased waist size.

Heber D et al.
J Agric Food Chem. 2007 Nov 28. 55(24): 10050-10054. EPub 2007 Oct 30.
A pomegranate ellagitannin-enriched polyphenol extract was prepared and administered to overweight individuals in two studies. Study 1 was designed for safety assessment, and study 2 for antioxidant assessment. It was observed that there were no serious adverse events in any subjects in either study, and there was evidence of antioxidant activity “through a significant reduction in TBARS linked with cardiovascular disease risk.”

The influence of pomegranate fruit extract in comparison to regular pomegranate juice and seed oil on nitric oxide and arterial function in obese Zucker rats.

deNigris F et al.
Nitric Oxide. 2007 Aug. 17(1): 50-54. EPub 2007 May 5. doi: 10.1016/j.niox.2007.04.005
Pomegranate fruit extract was shown to decrease the expression of vascular inflammation markers and increase plasma nitrate and nitrite levels in effects comparable to pomegranate juice in obese Zucker rats.

Effects of a pomegranate fruit extract rich in punicalagin on oxidation-sensitive genes and eNOS activity at sites of perturbed shear stress and atherogenesis.

deNigris F et al.
Cardiovasc Res. 2007 Jan 15. 73(2): 414-423. EPub 2006 Sep 01. doi: 10.1016/j.cardiores.2006.08.021
A pomegranate fruit extract rich in punicalagins was shown to reverse proatherogenic (promotion of fatty plaque build-up in the arteries) effects induced by shear stress through chronic administration.

Pomegranate juice ellagitannin metabolites are present in human plasma and some persist in urine for up to 48 hours.

Seeram NP et al.
J Nutr. 2006 Oct. 136(10): 2481-2485. doi: 10.1093/jn/136.10.2481
Demonstrates the length of time that polyphenols of pomegranate would persist in the human body after consumption.

Absorption, metabolism, and antioxidant effects of pomegranate (Punica granatum L) polyphenols after ingestion of a standardized extract [Pomella®] in healthy human volunteers.

Mertens-Talcott SU et al.
J Agric Food Chem. 2006 Sep 6. 54(23): 8956-8961. EPub 2006 Oct 13. doi: 10.1021/jf061674h
Pomella’s patented extraction process delivers an ellagitannin rich profile standardized to punicalagin content. A single dose of Pomella led to a significant 32% increase of antioxidant activity in the blood. Bioactive punicalagin derived metabolites were detected in half an hour after dosing.
View Full Study

Bioavailability of ellagic acid in human plasma after consumption of ellagitannins from promegranate (Punica granatum L) juice.

Seeram NP et al.
Clinica Chimica Acta. 2004 Apr 30. 348: 63-68. doi: 10.1016/j.cccn.2004.04.029
This study was the first to obtain direct evidence of the absorption of ellagic acids in a human from a food source. Biologically active ellagic acids and ellagitannins have important impacts on human health.

Evaluation of the bioavailability and metabolism in the rat of punicalagin, an antioxidant polyphenol from pomegranate juice.

Cerda B et al.
Eur J Nutr. 2003 Jan. 42(1): 18-28. doi: 10.1007/s/00394-003-0396-4

Pomegranate juice consumption inhibits serum angiotensin converting enzyme activity and reduces systolic blood pressure.

Aviram M et al.
Atherosclerosis. 2001 Sep. 158(1): 195-198. doi: 10.1016/s0021-9150(01)00412-9
Hypertensive patients consumed 50 mL of pomegranate juice (1.5 mmol of total polyphenols) per day for two weeks. A 36% decrement in ACE activity and a 5% reduction in systolic blood pressure were noted; reduction in ACE activity has been shown to attenuate atherosclerosis.
1 2 3