Longvida
Research

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Please note that the physiological activity of the ingredient(s) described herein is supported by the referenced clinical trial reports. Marketers of finished products containing the ingredient(s) described herein are responsible for determining whether claims made for such products are lawful and in compliance with the laws of the country in which they will market the products.

Longvida
Research

Longvida
Research

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Age-related alterations to working memory and to pyramidal neurons in the prefrontal cortex of rhesus monkeys begin in early middle-age and are partially ameliorated by dietary curcumin.

Chang W et al.
Neurobiol Aging. 16 Sept 2021. doi: 10.1016/j.neurobiolaging.2021.09.012
We compared the properties of L3 pyramidal neurons from the LPFC of behaviorally characterized rhesus monkeys over the adult lifespan using whole-cell patch clamp recordings and neuronal reconstructions.

Short term, oral supplementation with optimized curcumin does not impair performance improvements associated with high intensity interval training.

Kisiolek JN et al.
J Diet Suppl. 11Jun 2021. 0(0): pp 1-14. 2021, doi: 10.1080/19390211.2021.1936335.
Curcumin may improve athletic performance through a reduction in inflammation following exercise and improve mental states of well-being. The purpose of this investigation was to explore the effects of a 14 day HIIT intervention and oral supplementation with Longvida® optimized curcumin on athletic performance, lactate response, and well-being.

Preservation of dendritic spine morphology and postsynaptic signaling markers after treatment with solid lipid curcumin particles in the 5xFAD mouse model of AD amyloidosis.

Maiti P et al.
Alz Res Ther. 08 Feb 2021. 13(37): 1-22. doi: 10.1186/s13195-021-00769-9
Synaptic failure is one of the principal events associated with cognitive dysfunction in Alzheimer’s disease (AD). Preservation of existing synapses and prevention of synaptic loss are promising strategies to preserve cognitive function in AD patients. As a potent natural anti-oxidant, anti-amyloid, and anti-inflammatory polyphenol, curcumin (Cur) shows great promise as a therapy for AD.

Curcumin supplementation improves reversal learning in middle aged rhesus monkeys.

Uprety A et al.
Behav Neurosci. 2021. No BNE-2021-0237R2

Sectoral segmentation of retinal amyloid imaging in subjects with cognitive decline.

Dumitrascu OM et al.
Alz Dement: Diagno Assess Dise Monitor. 2020 Sept 28. 12(1): 1-10. doi: 10.1002/dad2.12109
Alzheimer's disease (AD) is a devastating neurodegenerative disorder and the most prevalent form of dementia, associated with enormous social and public health challenges. Considerable evidence supports that quantitative imaging of biofluid biomarkers of AD pathology, amyloid beta (Aβ), tau, and neurodegeneration, may be useful predictors of subsequent cognitive decline. Aβ is a pathological hallmark of AD, the target of disease-modifying therapies,3 and useful in discriminating AD from other neuropathologies.

Fish oil supplementation reduces osteoarthritis-specific pain in older adults with overweight/obesity.

Kuszewski JC et al.
Rheumatol Adv Pract. 2020 Jul 23. 4(2): 1-9. doi: 10.1093/rap/rkaa036
OA is a leading cause of chronic pain and disability. Next to inflammation, vascular pathology has been hypothesized to play a role in its aetiology and progression. Owing to side effects and the low efficacy of pharmacological treatments, dietary supplements are popular as alternative treatments, but evidence of efficacy is limited. We tested whether fish oil and curcumin supplementation can reduce chronic pain and OA burden in older adults.

Further evidence of benefits to mood and working memory from lipidated curcumin [Longvida] in healthy older people: A 12-week, double-blind, placebo-controlled, partial replication study.

Cox KHM et al.
Nutrients. 2020 Jun 04. 12(6): 1678. doi: 10.3390/nu12061678
A partial replication study by researchers at Swinburne University reveals Longvida® improves aspects of mood, memory, and working memory in a healthy older cohort. The pattern of results is consistent with improvements in hippocampal function and may hold promise for alleviating cognitive decline in some populations. This study examined a similar population with slightly elevated cognitive abilities, while eliciting similar results to the first clinical published in 2014 - see Cox KH et al, 2014.

Effects of fish oil and curcumin supplementation on cerebrovascular function in older adults: A randomized controlled trial.

Kuszewski JC et al.
Nutr Metab Cardiovasc Dis. 2020 Apr 12. 30(4): 625-633. EPub 2019 Dec 30. doi: 1016/j.numecd.2019.12.010
Longvida®, in combindation with fish oil, offered tangible health benefits with significant increase in HDL cholesterol (p=0.001) and attenuated a reduction in triglycerides, which is intriguing since triglycerides and HDLs are usually inversely related. Overall, the addition of Longvida to fish oil showed no contraindications, and that Longvida taken with fish oil does not appear to hinder the ability of Longvida to offer tangible health benefits. No serious adverse events were observed.

Effects of Solid, Lipid Curcumin Particles on alcohol metabolism - An expiatory and a randomized, double-blind, placebo-controlled, parallel-group crossover study.

Machida N et al.
Jpn Pharmacol Ther. 2020 Apr. 48(5): 867-873.
This study further provides evidence that Longvda curcumin is safe and efficacious. Previously examined in 2014, and recently published, researchers report reduced side effects typically associated with alcohol consumption and suggest that Longvida may offer liver health support through the acceleration of ethanol and acetaldehyde metabolism.

Exploring the relationship between optimized bioavailable curcumin and performance after an intensified training program.

Kisiolek JN et al.
Poster presentation. FASEB J. 2020 Apr. 34(S1): 1. doi: 10.1096/fasebj.2020.34.s1.05415
The purpose of this double blind, randomized, study was to determine the effects of Longvida® Optimized Curcumin on time trial performance time as well as the inflammatory mediator C-reactive protein (CRP) after 2 weeks of an intensified training program.

Effects of a solid lipid curcumin particle formulation on chronic activation of microglia and astroglia in the GFAP-IL6 mouse model.

Ullah F et al.
Sci Rep. 11 Feb 2020. 10(1): 1-19. doi: 10.1038/s41598-020-58838-2
Chronic glial activation is characterized by increased numbers of activated glial cells, secreting free radicals and cytotoxic cytokines, subsequently causing neuronal damage. In order to investigate the anti-inflammatory activity of Longvida® Optimised Curcumin (LC), we fed 500 ppm of LC to 2-month-old wild type and GFAP-IL6 mice for 6 months. LC feeding led to a significant reduction in the number of Iba-1+ microglia by 26% in the hippocampus and by 48% in the cerebellum, GFAP+ astrocytes by 30%, and TSPO+ cells by 24% in the hippocampus and by 31% in the cerebellum of the GFAP-IL6 mice.

A sensitive LC-MS assay using derivatization with boron trifluoride to quantify curcuminoids in biological samples.

Yoon AJ et al.
Analyt Biochem. 2020. 596: 113636. ISSN: 003-2697
A procedure is described to measure curcumin (C), demethoxycurcumin (DMC), bisdemethoxycurcumin (BDMC), tetrahydrocurcumim (TC) and their glucuronidated metabolites (CG, DMCG, and BDMCG) in plasma, brain, liver and tumor samples. The procedure involves converting the analytes to their boron difluoride derivatives and analyzing them by combined liquid chromatography coupled to an ion trap mass spectrometer operating in the negative ion MSⁿ scan mode.

An exploratory analysis of changes in mental wellbeing following curcumin and fish oil supplementation in middle-aged and older adults.

Kuszewski JC et al.
Nutrients. 2020. 12(10): 2902. doi: 10.3390/nu12102902
Curcumin has previously been shown to enhance mood in non-depressed older adults. However, observed benefits were limited to short-term supplementation (4 weeks). In a 16 week randomized, double-blind, placebo-controlled, 2 × 2 factorial design trial, we supplemented overweight or obese non-depressed adults (50–80 years) with curcumin (160 mg/day), fish oil (2000 mg docosahexaenoic acid +400 mg eicosapentaenoic acid/day), or a combination of both.

Effects of fish oil and curcumin supplementation on cerebrovascular function in older adults: A randomized controlled trial.

Kuszewski JC et al.
Nut Metab Cardiovasc Dis. 30 Dec 2019. 30(4): 625-633. doi: 10.1016/j.numecd.2019.12.010
Curcumin has previously been shown to enhance mood in non-depressed older adults. However, observed benefits were limited to short-term supplementation (4 weeks). In a 16 week randomized, double-blind, placebo-controlled, 2 × 2 factorial design trial, we supplemented overweight or obese non-depressed adults (50–80 years) with curcumin (160 mg/day), fish oil (2000 mg docosahexaenoic acid +400 mg eicosapentaenoic acid/day), or a combination of both.

Combination treatment of berberine and solid lipid curcumin particles increased cell death and inhibited PI3K/Akt/mTOR pathway of human cultured glioblastoma cells more effectively than did individual treatments.

Maiti P et al.
PLoS ONE. 16 Dec 2019. 14(12): 1-24. doi. 10.1371/journal.pone.0225660
The treatment of glioblastoma is challenging for the clinician, due to its chemotherapeutic resistance. Recent findings suggest that targeting glioblastoma using anti-cancer natural polyphenols is a promising strategy.

The cytoprotective benefits of a turmeric, quercetin, and rosemary blend through activation of the oxidative stress pathway.

Rajgopal A et al.
Pharmacognosy Magazine. 28 Nov 2019. 15(66): 449-454. doi: 10.4103/pm.pm_556_18
An imbalance between oxidative and reductive processes within cells can result in oxidative stress leading to a decrease in cellular survival. Use of natural products with antioxidant properties may reduce this oxidative stress.

Does acute improvement in muscle recovery with curcumin supplementation translate to long-term training?

McFarlin BK et al.
J Sci Sport Exer. 2019 Oct 30. EPub 2019 Nov 26. pp 1-5. doi: 10.1007/s42978-019-00045-1

A highly bioavailable curcumin extract improves neurocognitive function and mood in healthy older people: A 12-week randomized, double-blind, placebo-controlled trial (OR32-05-19).

Scholey A et al.
Current Dev Nut. 2019 Jun. Poster Presentation. Volume 3(Issue Supplement 1): nzz052.OR32–05–19. doi: 10.1093/cdn/nzz052.OR32-05-19
Previously, researchers at Swinburne University showed significant improvements in measures of memory, attention, fatigue, stress, and mood (Cox KH et al, 2015). This trial was a follow up to the results previously seen in 1 and 3 hrs and in 4-weeks. The results of this second trial further confirm that a single daily dose of 400mg of Longvida improves aspects of mood and working memory in healthy older adults, with measures at 12-weeks.

Curcumin and solid lipid curcumin particles induce autophagy, but inhibit mitophagy and the PI3K-Akt/mTOR pathway in cultured glioblastoma cells.

Maiti P et al.
Int J Mol Sci. 18 Jan 2019. 20(2): 399. doi: 10.3390/ijms20020399
Autophagy and the (PI3K-Akt/mTOR) signaling pathway play significant roles in glioblastoma multiforme (GBM) cell death and survival. Curcumin (Cur) has been reported to prevent several cancers, including GBM. However, the poor solubility and limited bioavailability of natural Cur limits its application in preventing GBM growth.

The anti-inflammatory potential of curcumin preparations on activated glial cell numbers and morphology in the GFAP-IL6 mouse brain.

Gyengesi E et al.
Poster presentation in: 2019 Neuroscience Meeting Planner. Chicago, IL; 2019: Program No. 539.04.

Curcumin supplementation alters inflammatory cytokines following exercise.

McFarlin BK et al.
Poster presentation. Med Sci Sport Exerc. 2019. 51: 90.
The study evaluated different doses and their impact post-exercise recovery and inflammation through perceived muscle soreness, inflammatory biomarkers, and muscle injury. 400mg and 1000mg/day doses were associated with a reduction in inflammatory signals and creatine kinase. Researchers indicated that the 1000mg/day dose was most effective at reducing subjective soreness and whole-body inflammation.

Dose-dependent effectiveness of optimized curcumin supplementation to alter inflammation following exertion-induced skeletal muscle injury.

McFarlin BK et al.
Poster presentation in: Autumn Immunology Conference. Chicago, IL. 2019.
The study evaluated different doses and their impact post-exercise recovery and inflammation through perceived muscle soreness, inflammatory biomarkers, and muscle injury. 400mg and 1000mg/day doses were associated with a reduction in inflammatory signals and creatine kinase. Researchers indicated that the 1000mg/day dose was most effective at reducing subjective soreness and whole-body inflammation.

Effects of composite supplement containing curcumin, ferulic acid, and soybean-derived phosphatidylserine on cognitive function in healthy middle-aged and senior adults – A randomized, double-blind, placebo-controlled, parallel-group study.

Kawamoto K et al.
Japanese Pharmacol Ther. 2019. 47: 1253-68.
Longvida®, in a blend, offered tangible health benefits to cognitive function including memory, attention, and judgement in healthy middle-aged and senior adults, with significant improvements to memory and attention in the Longvida group compared to placebo after 20 weeks. Longvida, as a blend, exhibited no side effects during the study.

The anti-inflammatory potential of curcumin preparations on activated glial cell numbers and morphology in the GFAP-IL6 mouse brain.

Gyengesi E.
Poster Presentation in: Neuroscience. Chicago, IL. 2019. Session 539 (Abstract 9909).
Long-term supplementation with Longvida offers support to neuroinflammatory biomarkers associated with neural inflammation through decreases in microglial activation.

A phase 1 open prospective cohort trial of curcumin plus tyrosine kinase inhibitors for EGFR-mutant advanced non-small cell lung.

Esfahani K et al.
J Clin Oncol. 2019. 37(15_suppl): e20611-e20611. doi: 10.1200/JCO.2019.37.15_suppl.e20611
This study further provides evidence that short-term use of Longvida curcumin in patients is feasible and safe. Researchers report high treatment adherence and improved quality of life with curcumin. These findings, as well as efficacy data and the effect of curcumin on other inflammation-associated biomarkers, warrant investigation in a larger phase 2 study.
  • Filter Research By Type:

  • Filter Research By Dosage:

Age-related alterations to working memory and to pyramidal neurons in the prefrontal cortex of rhesus monkeys begin in early middle-age and are partially ameliorated by dietary curcumin.

Chang W et al.
Neurobiol Aging. 16 Sept 2021. doi: 10.1016/j.neurobiolaging.2021.09.012
We compared the properties of L3 pyramidal neurons from the LPFC of behaviorally characterized rhesus monkeys over the adult lifespan using whole-cell patch clamp recordings and neuronal reconstructions.

Short term, oral supplementation with optimized curcumin does not impair performance improvements associated with high intensity interval training.

Kisiolek JN et al.
J Diet Suppl. 11Jun 2021. 0(0): pp 1-14. 2021, doi: 10.1080/19390211.2021.1936335.
Curcumin may improve athletic performance through a reduction in inflammation following exercise and improve mental states of well-being. The purpose of this investigation was to explore the effects of a 14 day HIIT intervention and oral supplementation with Longvida® optimized curcumin on athletic performance, lactate response, and well-being.

Preservation of dendritic spine morphology and postsynaptic signaling markers after treatment with solid lipid curcumin particles in the 5xFAD mouse model of AD amyloidosis.

Maiti P et al.
Alz Res Ther. 08 Feb 2021. 13(37): 1-22. doi: 10.1186/s13195-021-00769-9
Synaptic failure is one of the principal events associated with cognitive dysfunction in Alzheimer’s disease (AD). Preservation of existing synapses and prevention of synaptic loss are promising strategies to preserve cognitive function in AD patients. As a potent natural anti-oxidant, anti-amyloid, and anti-inflammatory polyphenol, curcumin (Cur) shows great promise as a therapy for AD.

Curcumin supplementation improves reversal learning in middle aged rhesus monkeys.

Uprety A et al.
Behav Neurosci. 2021. No BNE-2021-0237R2

Sectoral segmentation of retinal amyloid imaging in subjects with cognitive decline.

Dumitrascu OM et al.
Alz Dement: Diagno Assess Dise Monitor. 2020 Sept 28. 12(1): 1-10. doi: 10.1002/dad2.12109
Alzheimer's disease (AD) is a devastating neurodegenerative disorder and the most prevalent form of dementia, associated with enormous social and public health challenges. Considerable evidence supports that quantitative imaging of biofluid biomarkers of AD pathology, amyloid beta (Aβ), tau, and neurodegeneration, may be useful predictors of subsequent cognitive decline. Aβ is a pathological hallmark of AD, the target of disease-modifying therapies,3 and useful in discriminating AD from other neuropathologies.

Fish oil supplementation reduces osteoarthritis-specific pain in older adults with overweight/obesity.

Kuszewski JC et al.
Rheumatol Adv Pract. 2020 Jul 23. 4(2): 1-9. doi: 10.1093/rap/rkaa036
OA is a leading cause of chronic pain and disability. Next to inflammation, vascular pathology has been hypothesized to play a role in its aetiology and progression. Owing to side effects and the low efficacy of pharmacological treatments, dietary supplements are popular as alternative treatments, but evidence of efficacy is limited. We tested whether fish oil and curcumin supplementation can reduce chronic pain and OA burden in older adults.

Further evidence of benefits to mood and working memory from lipidated curcumin [Longvida] in healthy older people: A 12-week, double-blind, placebo-controlled, partial replication study.

Cox KHM et al.
Nutrients. 2020 Jun 04. 12(6): 1678. doi: 10.3390/nu12061678
A partial replication study by researchers at Swinburne University reveals Longvida® improves aspects of mood, memory, and working memory in a healthy older cohort. The pattern of results is consistent with improvements in hippocampal function and may hold promise for alleviating cognitive decline in some populations. This study examined a similar population with slightly elevated cognitive abilities, while eliciting similar results to the first clinical published in 2014 - see Cox KH et al, 2014.

Effects of fish oil and curcumin supplementation on cerebrovascular function in older adults: A randomized controlled trial.

Kuszewski JC et al.
Nutr Metab Cardiovasc Dis. 2020 Apr 12. 30(4): 625-633. EPub 2019 Dec 30. doi: 1016/j.numecd.2019.12.010
Longvida®, in combindation with fish oil, offered tangible health benefits with significant increase in HDL cholesterol (p=0.001) and attenuated a reduction in triglycerides, which is intriguing since triglycerides and HDLs are usually inversely related. Overall, the addition of Longvida to fish oil showed no contraindications, and that Longvida taken with fish oil does not appear to hinder the ability of Longvida to offer tangible health benefits. No serious adverse events were observed.

Effects of Solid, Lipid Curcumin Particles on alcohol metabolism - An expiatory and a randomized, double-blind, placebo-controlled, parallel-group crossover study.

Machida N et al.
Jpn Pharmacol Ther. 2020 Apr. 48(5): 867-873.
This study further provides evidence that Longvda curcumin is safe and efficacious. Previously examined in 2014, and recently published, researchers report reduced side effects typically associated with alcohol consumption and suggest that Longvida may offer liver health support through the acceleration of ethanol and acetaldehyde metabolism.

Exploring the relationship between optimized bioavailable curcumin and performance after an intensified training program.

Kisiolek JN et al.
Poster presentation. FASEB J. 2020 Apr. 34(S1): 1. doi: 10.1096/fasebj.2020.34.s1.05415
The purpose of this double blind, randomized, study was to determine the effects of Longvida® Optimized Curcumin on time trial performance time as well as the inflammatory mediator C-reactive protein (CRP) after 2 weeks of an intensified training program.

Effects of a solid lipid curcumin particle formulation on chronic activation of microglia and astroglia in the GFAP-IL6 mouse model.

Ullah F et al.
Sci Rep. 11 Feb 2020. 10(1): 1-19. doi: 10.1038/s41598-020-58838-2
Chronic glial activation is characterized by increased numbers of activated glial cells, secreting free radicals and cytotoxic cytokines, subsequently causing neuronal damage. In order to investigate the anti-inflammatory activity of Longvida® Optimised Curcumin (LC), we fed 500 ppm of LC to 2-month-old wild type and GFAP-IL6 mice for 6 months. LC feeding led to a significant reduction in the number of Iba-1+ microglia by 26% in the hippocampus and by 48% in the cerebellum, GFAP+ astrocytes by 30%, and TSPO+ cells by 24% in the hippocampus and by 31% in the cerebellum of the GFAP-IL6 mice.

A sensitive LC-MS assay using derivatization with boron trifluoride to quantify curcuminoids in biological samples.

Yoon AJ et al.
Analyt Biochem. 2020. 596: 113636. ISSN: 003-2697
A procedure is described to measure curcumin (C), demethoxycurcumin (DMC), bisdemethoxycurcumin (BDMC), tetrahydrocurcumim (TC) and their glucuronidated metabolites (CG, DMCG, and BDMCG) in plasma, brain, liver and tumor samples. The procedure involves converting the analytes to their boron difluoride derivatives and analyzing them by combined liquid chromatography coupled to an ion trap mass spectrometer operating in the negative ion MSⁿ scan mode.

An exploratory analysis of changes in mental wellbeing following curcumin and fish oil supplementation in middle-aged and older adults.

Kuszewski JC et al.
Nutrients. 2020. 12(10): 2902. doi: 10.3390/nu12102902
Curcumin has previously been shown to enhance mood in non-depressed older adults. However, observed benefits were limited to short-term supplementation (4 weeks). In a 16 week randomized, double-blind, placebo-controlled, 2 × 2 factorial design trial, we supplemented overweight or obese non-depressed adults (50–80 years) with curcumin (160 mg/day), fish oil (2000 mg docosahexaenoic acid +400 mg eicosapentaenoic acid/day), or a combination of both.

Effects of fish oil and curcumin supplementation on cerebrovascular function in older adults: A randomized controlled trial.

Kuszewski JC et al.
Nut Metab Cardiovasc Dis. 30 Dec 2019. 30(4): 625-633. doi: 10.1016/j.numecd.2019.12.010
Curcumin has previously been shown to enhance mood in non-depressed older adults. However, observed benefits were limited to short-term supplementation (4 weeks). In a 16 week randomized, double-blind, placebo-controlled, 2 × 2 factorial design trial, we supplemented overweight or obese non-depressed adults (50–80 years) with curcumin (160 mg/day), fish oil (2000 mg docosahexaenoic acid +400 mg eicosapentaenoic acid/day), or a combination of both.

Combination treatment of berberine and solid lipid curcumin particles increased cell death and inhibited PI3K/Akt/mTOR pathway of human cultured glioblastoma cells more effectively than did individual treatments.

Maiti P et al.
PLoS ONE. 16 Dec 2019. 14(12): 1-24. doi. 10.1371/journal.pone.0225660
The treatment of glioblastoma is challenging for the clinician, due to its chemotherapeutic resistance. Recent findings suggest that targeting glioblastoma using anti-cancer natural polyphenols is a promising strategy.

The cytoprotective benefits of a turmeric, quercetin, and rosemary blend through activation of the oxidative stress pathway.

Rajgopal A et al.
Pharmacognosy Magazine. 28 Nov 2019. 15(66): 449-454. doi: 10.4103/pm.pm_556_18
An imbalance between oxidative and reductive processes within cells can result in oxidative stress leading to a decrease in cellular survival. Use of natural products with antioxidant properties may reduce this oxidative stress.

Does acute improvement in muscle recovery with curcumin supplementation translate to long-term training?

McFarlin BK et al.
J Sci Sport Exer. 2019 Oct 30. EPub 2019 Nov 26. pp 1-5. doi: 10.1007/s42978-019-00045-1

A highly bioavailable curcumin extract improves neurocognitive function and mood in healthy older people: A 12-week randomized, double-blind, placebo-controlled trial (OR32-05-19).

Scholey A et al.
Current Dev Nut. 2019 Jun. Poster Presentation. Volume 3(Issue Supplement 1): nzz052.OR32–05–19. doi: 10.1093/cdn/nzz052.OR32-05-19
Previously, researchers at Swinburne University showed significant improvements in measures of memory, attention, fatigue, stress, and mood (Cox KH et al, 2015). This trial was a follow up to the results previously seen in 1 and 3 hrs and in 4-weeks. The results of this second trial further confirm that a single daily dose of 400mg of Longvida improves aspects of mood and working memory in healthy older adults, with measures at 12-weeks.

Curcumin and solid lipid curcumin particles induce autophagy, but inhibit mitophagy and the PI3K-Akt/mTOR pathway in cultured glioblastoma cells.

Maiti P et al.
Int J Mol Sci. 18 Jan 2019. 20(2): 399. doi: 10.3390/ijms20020399
Autophagy and the (PI3K-Akt/mTOR) signaling pathway play significant roles in glioblastoma multiforme (GBM) cell death and survival. Curcumin (Cur) has been reported to prevent several cancers, including GBM. However, the poor solubility and limited bioavailability of natural Cur limits its application in preventing GBM growth.

The anti-inflammatory potential of curcumin preparations on activated glial cell numbers and morphology in the GFAP-IL6 mouse brain.

Gyengesi E et al.
Poster presentation in: 2019 Neuroscience Meeting Planner. Chicago, IL; 2019: Program No. 539.04.

Curcumin supplementation alters inflammatory cytokines following exercise.

McFarlin BK et al.
Poster presentation. Med Sci Sport Exerc. 2019. 51: 90.
The study evaluated different doses and their impact post-exercise recovery and inflammation through perceived muscle soreness, inflammatory biomarkers, and muscle injury. 400mg and 1000mg/day doses were associated with a reduction in inflammatory signals and creatine kinase. Researchers indicated that the 1000mg/day dose was most effective at reducing subjective soreness and whole-body inflammation.

Dose-dependent effectiveness of optimized curcumin supplementation to alter inflammation following exertion-induced skeletal muscle injury.

McFarlin BK et al.
Poster presentation in: Autumn Immunology Conference. Chicago, IL. 2019.
The study evaluated different doses and their impact post-exercise recovery and inflammation through perceived muscle soreness, inflammatory biomarkers, and muscle injury. 400mg and 1000mg/day doses were associated with a reduction in inflammatory signals and creatine kinase. Researchers indicated that the 1000mg/day dose was most effective at reducing subjective soreness and whole-body inflammation.

Effects of composite supplement containing curcumin, ferulic acid, and soybean-derived phosphatidylserine on cognitive function in healthy middle-aged and senior adults – A randomized, double-blind, placebo-controlled, parallel-group study.

Kawamoto K et al.
Japanese Pharmacol Ther. 2019. 47: 1253-68.
Longvida®, in a blend, offered tangible health benefits to cognitive function including memory, attention, and judgement in healthy middle-aged and senior adults, with significant improvements to memory and attention in the Longvida group compared to placebo after 20 weeks. Longvida, as a blend, exhibited no side effects during the study.

The anti-inflammatory potential of curcumin preparations on activated glial cell numbers and morphology in the GFAP-IL6 mouse brain.

Gyengesi E.
Poster Presentation in: Neuroscience. Chicago, IL. 2019. Session 539 (Abstract 9909).
Long-term supplementation with Longvida offers support to neuroinflammatory biomarkers associated with neural inflammation through decreases in microglial activation.

A phase 1 open prospective cohort trial of curcumin plus tyrosine kinase inhibitors for EGFR-mutant advanced non-small cell lung.

Esfahani K et al.
J Clin Oncol. 2019. 37(15_suppl): e20611-e20611. doi: 10.1200/JCO.2019.37.15_suppl.e20611
This study further provides evidence that short-term use of Longvida curcumin in patients is feasible and safe. Researchers report high treatment adherence and improved quality of life with curcumin. These findings, as well as efficacy data and the effect of curcumin on other inflammation-associated biomarkers, warrant investigation in a larger phase 2 study.