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Please note that the physiological activity of the ingredient(s) described herein is supported by the referenced clinical trial reports. Marketers of finished products containing the ingredient(s) described herein are responsible for determining whether claims made for such products are lawful and in compliance with the laws of the country in which they will market the products.



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Effect of an oral supplement containing curcumin extract (Longvida®) on lameness due to OA and gastric ulcer scores.

Andrews FM et al.
Equine Vet Educ. 2022. 1-12. doi: 10.1111/eve.13616

Effects of nutrition on cognitive function in adults with or without cognitive impairment: A systematic review of randomized controlled clinical trials.

Gutierrez L et al.
Nutrients. 22 Oct 2021. 13(11): 3728. doi: 10.3390/nu13113728

Age-related alterations to working memory and to pyramidal neurons in the prefrontal cortex of rhesus monkeys begin in early middle-age and are partially ameliorated by dietary curcumin.

Chang W et al.
Neurobiol Aging. 16 Sept 2021. doi: 10.1016/j.neurobiolaging.2021.09.012
We compared the properties of L3 pyramidal neurons from the LPFC of behaviorally characterized rhesus monkeys over the adult lifespan using whole-cell patch clamp recordings and neuronal reconstructions.

Retinal amyloid imaging for screening AD.

Tadokoro K et al.
J Alz Dis. Aug 2021. 83(2): 927-934. doi: 10.3233/JAD-210327
The present noninvasive in vivo detection of retinal amyloid deposition is useful for screening patients.

Short term, oral supplementation with optimized curcumin does not impair performance improvements associated with high intensity interval training.

Kisiolek JN et al.
J Diet Suppl. 11Jun 2021. 0(0): pp 1-14. 2021, doi: 10.1080/19390211.2021.1936335.
Curcumin may improve athletic performance through a reduction in inflammation following exercise and improve mental states of well-being. The purpose of this investigation was to explore the effects of a 14 day HIIT intervention and oral supplementation with Longvida® optimized curcumin on athletic performance, lactate response, and well-being.

Feasibility study for detection of retinal amyloid in clinical trials: The anti‐amyloid treatment in asymptomatic AD (A4) trial.

Ngolab J et al.
Alz Dement. 25 May 2021. 13(1): e12199. doi: 10.1002/dad2.12199
Longvida was used to quantify amyloid plaques in the retina of patients. Longvida was safe and efficacious.

Preservation of dendritic spine morphology and postsynaptic signaling markers after treatment with solid lipid curcumin particles in the 5xFAD mouse model of AD amyloidosis.

Maiti P et al.
Alz Res Ther. 08 Feb 2021. 13(37): 1-22. doi: 10.1186/s13195-021-00769-9
Synaptic failure is one of the principal events associated with cognitive dysfunction in Alzheimer’s disease (AD). Preservation of existing synapses and pre