Longvida®
Research
Longvida®
Research
Don’t see what you’re looking for? All additional research is categorized under supportive research.
A phase 1 open prospective cohort trial of curcumin plus tyrosine kinase inhibitors for EGFR-mutant advanced non-small cell lung.
Esfahani K et al.
J Clin Oncol. 2019. 37(15_suppl): e20611-e20611. doi: 10.1200/JCO.2019.37.15_suppl.e20611
This study further provides evidence that short-term use of Longvida curcumin in patients is feasible and safe. Researchers report high treatment adherence and improved quality of life with curcumin. These findings, as well as efficacy data and the effect of curcumin on other inflammation-associated biomarkers, warrant investigation in a larger phase 2 study.
Curcumin improves hippocampal function in healthy older adults: A three month randomized controlled trial.
Scholey A et al.
Poster Presentation in: 13th European Nutrition Conference Malnutrition in an Obese World: European Perspectives (FENS). Dublin, Ireland. 2019: P3-01-02.
Additional results confirm that Longvida improves aspects of mood, memory, and working memory in a healthy older cohort. The pattern of results is consistent with improvements in hippocampal function and may hold promise for alleviating cognitive decline in some populations.
Evaluation of the efficacy and safety of capsule Longvida® Optimized Curcumin (solid lipid curcumin particles) in knee: A pilot clinical study.
Gupte PA et al.
J Inflamm Res. 2019. 12: 145-152. doi: 10.2147/JIR.S205390
A comparative examination of Longvida showed that administration was not only faster-acting and safe, but had equal efficacy to the control.
High-dose, short-term Longvida® Optimized Curcumin® supplementation is associated with improved inflammatory response to eccentric muscle injury.
Tanner EA et al.
2018 Nov. Poster presentation in AHPA Botanical Congress 2018 in Las Vegas, NV, USA.
The study evaluated different doses and their impact post-exercise recovery and inflammation through perceived muscle soreness, inflammatory biomarkers, and muscle injury. 400mg and 1000mg/day doses were associated with a reduction in inflammatory signals and creatine kinase. Researchers indicated that the 1000mg/day dose was most effective at reducing subjective soreness and whole-body inflammation.
Long-term effects of curcumin in the non-human primate brain.
Bang-Bon Koo et al.
Brain Res Bulletin. 2018 Jul 04. doi: 10.1016/j.brainresbull.2018.06.015
Researchers at Boston University studied the effect of oral doses of Longvida Optimized Curcumin on cognition in middle-aged rhesus monkeys and reported a delayed pattern of decline in their spatial working memory and motor function. A first of its kind, this long-term (14–18 months) study examined the effect of curcumin treatments using in-vivo imaging assessments to establish the morphological basis for how curcumin acts to improve cognition and motor skills in an aging primate model.
Oral curcumin supplementation improves fine motor function in middle-aged rhesus monkey.
Moore TL et al.
Somatosens Motor Res. 2018 Feb 15. doi: 10.1080/08990220.2018.1432481
Chronic curcumin treatment improves spatial working memory but not recognition memory in middle-aged rhesus monkeys.
Moore TL et al.
GeroSci. 2017 Dec. 39(5-6): 571-584. EPub 2017 Oct 18. doi: 10.1007/s11357-017-9998-2
Effect of Absorbine Bute-Less Performance supplement containing curcumim extract (Longvida SD Optimized Curcumin®) in horses with osteoarthritis or degenerative joint disease. Poster presentation in American Association of Equine Practitioners (AAEP).
Andrews FM et al.
2017 Dec. Retrieved July 2019
Researchers concluded that Longvida® fed to horses improved lameness due to OA after 30-days of feeding, while maintaining stomach health. Longvida® was well tolerated and no adverse events were observed.
Solid lipid curcumin particles induce more DNA fragmentation and cell death in cultured human cells than does natural curcumin.
Maiti P et al.
Oxidat Med Cell Longev. 2017 Nov 19. Vol 2017(Article ID 9656719). 17pgs. doi: 10.1155/2017/9656719
Curcumin ameliorates neuroinflammation, neuodegeneration, and memory deficits in p25 transgenic mouse model.
Sundaram JR et al.
J Alz D. EPub 2017 Nov 7. 60(4): 1429-1442. doi: 10.3233/JAD-170093
The results of this study showed that Longvida Optimized Curcumin effectively counteracted p25-mediated glial activation and pro-inflammatory chemokine/cytokine production. Further, it reduced the progression of p25-induced tau/amyloid pathology and, in turn, ameliorated induced cognitive impairments.
Comparative neuroprotective effects of dietary curcumin and solid lipid curcumin particles in cultured mouse neuroblastoma cells after exposure to Aβ42.
Maiti P et al.
Int J Alz Dis. 2017 Apr 16. Vol 2017(Art ID 4164872): 13 pgs. doi: 10.1155/2017/4164872.
Longvida showed greater permeability when compared to unformulated 95% curcumin and significantly decreased A?-induced reactive oxygen species (ROS) production, phosphorylated tau, and prevented apoptotic (cell) death at lower doses. These conclusions are supported by a previous pK study on Longvida and preclinical studies which showed enhanced bioavailability and permeability of Longvida compared to unformulated 95% curcumin extract, its benefits on neuroinflammation, and the ability to cross the BBB and other tissues in the body in the free form. This study showed additional evidence that Longvida has neuroprotective effects and might be more effective in controlling A?42-exposed neuronal death, relative to 95% curcumin extract.
Curcumin supplementation improves vascular endothelial function in healthy middle-aged and older adults by increasing nitric oxide bioavailability and reducing oxidative stress.
Santos-Parker JR et al.
Aging. 2017 Jan. 3. Vol 9(No1): 187-208.
Pharmacokinetics of Longvida®: Dose-concentration correlation.
Koronyo et al.
JCI Insight. 2017. 2(16): e93621 – Supplemental Data. doi: 10.1172/jci.insight.93621
Pilot studies demonstrating absorption and metabolism of Longvida using various dosage forms.
Retinal amyloid pathology and proof-of-concept imaging trial.
Koronyo, Y et al.
JCI Insight. 2017. 2(16). doi: 10.1172/jci.insight.93621
A proof-of-concept retinal imaging trial showing increased fluorescent intensity in retinal amyloid deposits and the highest brain concentrations of free curcumin obtained with Longvida Optimized Curcumin. This trial confirmed one more time the ability of Longvida to deliver free curcumin to targeted tissues, more specifically the brain and retina, and to support cognitive and complete neuronal health. *Winner of NutraIngredients-USA Nutrition Research Project of the Year 2019 for ground-breaking initiatives as "most innovative and impactful nutrition research project pushing the boundaries of nutritional science." Read more here.
Development of a neuroprotective potential algorithm for medicinal plants.
Liu W et al.
University of Rhode Island. Neurochem Int. 2016 Sep 29. 100: 164-177.
As part of a strategy to help guide the selection and evaluation of medicinal plant candidates for their neuroprotective potential, researchers at the University of Rhode Island developed a Neuroprotective Potential Algorithm (NPA) by evaluating twenty-three standardized and chemically characterized Ayurvedic medicinal plant extracts in a panel of bioassays targeting oxidative stress, carbonyl stress, protein glycation, amyloid beta (Aβ) fibrillation, acetylcholinesterase (AChE) inhibition, and neuroinflammation.
Don’t see what you’re looking for? All additional research is categorized under supportive research.
A phase 1 open prospective cohort trial of curcumin plus tyrosine kinase inhibitors for EGFR-mutant advanced non-small cell lung.
Esfahani K et al.
J Clin Oncol. 2019. 37(15_suppl): e20611-e20611. doi: 10.1200/JCO.2019.37.15_suppl.e20611
This study further provides evidence that short-term use of Longvida curcumin in patients is feasible and safe. Researchers report high treatment adherence and improved quality of life with curcumin. These findings, as well as efficacy data and the effect of curcumin on other inflammation-associated biomarkers, warrant investigation in a larger phase 2 study.
Curcumin improves hippocampal function in healthy older adults: A three month randomized controlled trial.
Scholey A et al.
Poster Presentation in: 13th European Nutrition Conference Malnutrition in an Obese World: European Perspectives (FENS). Dublin, Ireland. 2019: P3-01-02.
Additional results confirm that Longvida improves aspects of mood, memory, and working memory in a healthy older cohort. The pattern of results is consistent with improvements in hippocampal function and may hold promise for alleviating cognitive decline in some populations.
Evaluation of the efficacy and safety of capsule Longvida® Optimized Curcumin (solid lipid curcumin particles) in knee: A pilot clinical study.
Gupte PA et al.
J Inflamm Res. 2019. 12: 145-152. doi: 10.2147/JIR.S205390
A comparative examination of Longvida showed that administration was not only faster-acting and safe, but had equal efficacy to the control.
High-dose, short-term Longvida® Optimized Curcumin® supplementation is associated with improved inflammatory response to eccentric muscle injury.
Tanner EA et al.
2018 Nov. Poster presentation in AHPA Botanical Congress 2018 in Las Vegas, NV, USA.
The study evaluated different doses and their impact post-exercise recovery and inflammation through perceived muscle soreness, inflammatory biomarkers, and muscle injury. 400mg and 1000mg/day doses were associated with a reduction in inflammatory signals and creatine kinase. Researchers indicated that the 1000mg/day dose was most effective at reducing subjective soreness and whole-body inflammation.
Long-term effects of curcumin in the non-human primate brain.
Bang-Bon Koo et al.
Brain Res Bulletin. 2018 Jul 04. doi: 10.1016/j.brainresbull.2018.06.015
Researchers at Boston University studied the effect of oral doses of Longvida Optimized Curcumin on cognition in middle-aged rhesus monkeys and reported a delayed pattern of decline in their spatial working memory and motor function. A first of its kind, this long-term (14–18 months) study examined the effect of curcumin treatments using in-vivo imaging assessments to establish the morphological basis for how curcumin acts to improve cognition and motor skills in an aging primate model.
Oral curcumin supplementation improves fine motor function in middle-aged rhesus monkey.
Moore TL et al.
Somatosens Motor Res. 2018 Feb 15. doi: 10.1080/08990220.2018.1432481
Chronic curcumin treatment improves spatial working memory but not recognition memory in middle-aged rhesus monkeys.
Moore TL et al.
GeroSci. 2017 Dec. 39(5-6): 571-584. EPub 2017 Oct 18. doi: 10.1007/s11357-017-9998-2
Effect of Absorbine Bute-Less Performance supplement containing curcumim extract (Longvida SD Optimized Curcumin®) in horses with osteoarthritis or degenerative joint disease. Poster presentation in American Association of Equine Practitioners (AAEP).
Andrews FM et al.
2017 Dec. Retrieved July 2019
Researchers concluded that Longvida® fed to horses improved lameness due to OA after 30-days of feeding, while maintaining stomach health. Longvida® was well tolerated and no adverse events were observed.
Solid lipid curcumin particles induce more DNA fragmentation and cell death in cultured human cells than does natural curcumin.
Maiti P et al.
Oxidat Med Cell Longev. 2017 Nov 19. Vol 2017(Article ID 9656719). 17pgs. doi: 10.1155/2017/9656719
Curcumin ameliorates neuroinflammation, neuodegeneration, and memory deficits in p25 transgenic mouse model.
Sundaram JR et al.
J Alz D. EPub 2017 Nov 7. 60(4): 1429-1442. doi: 10.3233/JAD-170093
The results of this study showed that Longvida Optimized Curcumin effectively counteracted p25-mediated glial activation and pro-inflammatory chemokine/cytokine production. Further, it reduced the progression of p25-induced tau/amyloid pathology and, in turn, ameliorated induced cognitive impairments.
Comparative neuroprotective effects of dietary curcumin and solid lipid curcumin particles in cultured mouse neuroblastoma cells after exposure to Aβ42.
Maiti P et al.
Int J Alz Dis. 2017 Apr 16. Vol 2017(Art ID 4164872): 13 pgs. doi: 10.1155/2017/4164872.
Longvida showed greater permeability when compared to unformulated 95% curcumin and significantly decreased A?-induced reactive oxygen species (ROS) production, phosphorylated tau, and prevented apoptotic (cell) death at lower doses. These conclusions are supported by a previous pK study on Longvida and preclinical studies which showed enhanced bioavailability and permeability of Longvida compared to unformulated 95% curcumin extract, its benefits on neuroinflammation, and the ability to cross the BBB and other tissues in the body in the free form. This study showed additional evidence that Longvida has neuroprotective effects and might be more effective in controlling A?42-exposed neuronal death, relative to 95% curcumin extract.
Curcumin supplementation improves vascular endothelial function in healthy middle-aged and older adults by increasing nitric oxide bioavailability and reducing oxidative stress.
Santos-Parker JR et al.
Aging. 2017 Jan. 3. Vol 9(No1): 187-208.
Pharmacokinetics of Longvida®: Dose-concentration correlation.
Koronyo et al.
JCI Insight. 2017. 2(16): e93621 – Supplemental Data. doi: 10.1172/jci.insight.93621
Pilot studies demonstrating absorption and metabolism of Longvida using various dosage forms.
Retinal amyloid pathology and proof-of-concept imaging trial.
Koronyo, Y et al.
JCI Insight. 2017. 2(16). doi: 10.1172/jci.insight.93621
A proof-of-concept retinal imaging trial showing increased fluorescent intensity in retinal amyloid deposits and the highest brain concentrations of free curcumin obtained with Longvida Optimized Curcumin. This trial confirmed one more time the ability of Longvida to deliver free curcumin to targeted tissues, more specifically the brain and retina, and to support cognitive and complete neuronal health. *Winner of NutraIngredients-USA Nutrition Research Project of the Year 2019 for ground-breaking initiatives as "most innovative and impactful nutrition research project pushing the boundaries of nutritional science." Read more here.
Development of a neuroprotective potential algorithm for medicinal plants.
Liu W et al.
University of Rhode Island. Neurochem Int. 2016 Sep 29. 100: 164-177.
As part of a strategy to help guide the selection and evaluation of medicinal plant candidates for their neuroprotective potential, researchers at the University of Rhode Island developed a Neuroprotective Potential Algorithm (NPA) by evaluating twenty-three standardized and chemically characterized Ayurvedic medicinal plant extracts in a panel of bioassays targeting oxidative stress, carbonyl stress, protein glycation, amyloid beta (Aβ) fibrillation, acetylcholinesterase (AChE) inhibition, and neuroinflammation.
