Longvida®
Research
Longvida®
Research
Don’t see what you’re looking for? All additional research is categorized under supportive research.
Effects of a solid lipid curcumin particle formulation on chronic activation of microglia and astroglia in the GFAP-IL6 mouse model.
Ullah F et al.
Sci Rep. 11 Feb 2020. 10(1): 1-19. doi: 10.1038/s41598-020-58838-2
Chronic glial activation is characterized by increased numbers of activated glial cells, secreting free radicals and cytotoxic cytokines, subsequently causing neuronal damage. In order to investigate the anti-inflammatory activity of Longvida® Optimised Curcumin (LC), we fed 500 ppm of LC to 2-month-old wild type and GFAP-IL6 mice for 6 months. LC feeding led to a significant reduction in the number of Iba-1+ microglia by 26% in the hippocampus and by 48% in the cerebellum, GFAP+ astrocytes by 30%, and TSPO+ cells by 24% in the hippocampus and by 31% in the cerebellum of the GFAP-IL6 mice.
A sensitive LC-MS assay using derivatization with boron trifluoride to quantify curcuminoids in biological samples.
Yoon AJ et al.
Analyt Biochem. 2020. 596: 113636. ISSN: 003-2697
A procedure is described to measure curcumin (C), demethoxycurcumin (DMC), bisdemethoxycurcumin (BDMC), tetrahydrocurcumim (TC) and their glucuronidated metabolites (CG, DMCG, and BDMCG) in plasma, brain, liver and tumor samples. The procedure involves converting the analytes to their boron difluoride derivatives and analyzing them by combined liquid chromatography coupled to an ion trap mass spectrometer operating in the negative ion MSⁿ scan mode.
An exploratory analysis of changes in mental wellbeing following curcumin and fish oil supplementation in middle-aged and older adults.
Kuszewski JC et al.
Nutrients. 2020. 12(10): 2902. doi: 10.3390/nu12102902
Curcumin has previously been shown to enhance mood in non-depressed older adults. However, observed benefits were limited to short-term supplementation (4 weeks). In a 16 week randomized, double-blind, placebo-controlled, 2 × 2 factorial design trial, we supplemented overweight or obese non-depressed adults (50–80 years) with curcumin (160 mg/day), fish oil (2000 mg docosahexaenoic acid +400 mg eicosapentaenoic acid/day), or a combination of both.
Effects of fish oil and curcumin supplementation on cerebrovascular function in older adults: A randomized controlled trial.
Kuszewski JC et al.
Nut Metab Cardiovasc Dis. 30 Dec 2019. 30(4): 625-633. doi: 10.1016/j.numecd.2019.12.010
Curcumin has previously been shown to enhance mood in non-depressed older adults. However, observed benefits were limited to short-term supplementation (4 weeks). In a 16 week randomized, double-blind, placebo-controlled, 2 × 2 factorial design trial, we supplemented overweight or obese non-depressed adults (50–80 years) with curcumin (160 mg/day), fish oil (2000 mg docosahexaenoic acid +400 mg eicosapentaenoic acid/day), or a combination of both.
Combination treatment of berberine and solid lipid curcumin particles increased cell death and inhibited PI3K/Akt/mTOR pathway of human cultured glioblastoma cells more effectively than did individual treatments.
Maiti P et al.
PLoS ONE. 16 Dec 2019. 14(12): 1-24. doi. 10.1371/journal.pone.0225660
The cytoprotective benefits of a turmeric, quercetin, and rosemary blend through activation of the oxidative stress pathway.
Rajgopal A et al.
Pharmacognosy Magazine. 28 Nov 2019. 15(66): 449-454. doi: 10.4103/pm.pm_556_18
An imbalance between oxidative and reductive processes within cells can result in oxidative stress leading to a decrease in cellular survival. Use of natural products with antioxidant properties may reduce this oxidative stress.
Does acute improvement in muscle recovery with curcumin supplementation translate to long-term training?
McFarlin BK et al.
J Sci Sport Exer. 2019 Oct 30. EPub 2019 Nov 26. pp 1-5. doi: 10.1007/s42978-019-00045-1
A highly bioavailable curcumin extract improves neurocognitive function and mood in healthy older people: A 12-week randomized, double-blind, placebo-controlled trial (OR32-05-19).
Scholey A et al.
Current Dev Nut. 2019 Jun. Poster Presentation. Volume 3(Issue Supplement 1): nzz052.OR32–05–19. doi: 10.1093/cdn/nzz052.OR32-05-19
Previously, researchers at Swinburne University showed significant improvements in measures of memory, attention, fatigue, stress, and mood (Cox KH et al, 2015). This trial was a follow up to the results previously seen in 1 and 3 hrs and in 4-weeks. The results of this second trial further confirm that a single daily dose of 400mg of Longvida improves aspects of mood and working memory in healthy older adults, with measures at 12-weeks.
Effect of an oral supplement containing curcumin extract (Longvida®) on lameness due to osteoarthritis and gastric ulcer soreness.
Andrews FM et al
Poster Presentation 2019
See 2022 publication for full reference.
Curcumin and solid lipid curcumin particles induce autophagy, but inhibit mitophagy and the PI3K-Akt/mTOR pathway in cultured glioblastoma cells.
Maiti P et al.
Int J Mol Sci. 18 Jan 2019. 20(2): 399. doi: 10.3390/ijms20020399
Autophagy and the (PI3K-Akt/mTOR) signaling pathway play significant roles in glioblastoma multiforme (GBM) cell death and survival. Curcumin (Cur) has been reported to prevent several cancers, including GBM. However, the poor solubility and limited bioavailability of natural Cur limits its application in preventing GBM growth.
The anti-inflammatory potential of curcumin preparations on activated glial cell numbers and morphology in the GFAP-IL6 mouse brain.
Gyengesi E et al.
Poster presentation in: 2019 Neuroscience Meeting Planner. Chicago, IL; 2019: Program No. 539.04.
Curcumin supplementation alters inflammatory cytokines following exercise.
McFarlin BK et al.
Poster presentation. Med Sci Sport Exerc. 2019. 51: 90.
The study evaluated different doses and their impact post-exercise recovery and inflammation through perceived muscle soreness, inflammatory biomarkers, and muscle injury. 400mg and 1000mg/day doses were associated with a reduction in inflammatory signals and creatine kinase. Researchers indicated that the 1000mg/day dose was most effective at reducing subjective soreness and whole-body inflammation.
Dose-dependent effectiveness of optimized curcumin supplementation to alter inflammation following exertion-induced skeletal muscle injury.
McFarlin BK et al.
Poster presentation in: Autumn Immunology Conference. Chicago, IL. 2019.
The study evaluated different doses and their impact post-exercise recovery and inflammation through perceived muscle soreness, inflammatory biomarkers, and muscle injury. 400mg and 1000mg/day doses were associated with a reduction in inflammatory signals and creatine kinase. Researchers indicated that the 1000mg/day dose was most effective at reducing subjective soreness and whole-body inflammation.
Effects of composite supplement containing curcumin, ferulic acid, and soybean-derived phosphatidylserine on cognitive function in healthy middle-aged and senior adults – A randomized, double-blind, placebo-controlled, parallel-group study.
Kawamoto K et al.
Japanese Pharmacol Ther. 2019. 47: 1253-68.
Longvida®, in a blend, offered tangible health benefits to cognitive function including memory, attention, and judgement in healthy middle-aged and senior adults, with significant improvements to memory and attention in the Longvida group compared to placebo after 20 weeks. Longvida, as a blend, exhibited no side effects during the study.
The anti-inflammatory potential of curcumin preparations on activated glial cell numbers and morphology in the GFAP-IL6 mouse brain.
Gyengesi E.
Poster Presentation in: Neuroscience. Chicago, IL. 2019. Session 539 (Abstract 9909).
Long-term supplementation with Longvida offers support to neuroinflammatory biomarkers associated with neural inflammation through decreases in microglial activation.
Don’t see what you’re looking for? All additional research is categorized under supportive research.
Effects of a solid lipid curcumin particle formulation on chronic activation of microglia and astroglia in the GFAP-IL6 mouse model.
Ullah F et al.
Sci Rep. 11 Feb 2020. 10(1): 1-19. doi: 10.1038/s41598-020-58838-2
Chronic glial activation is characterized by increased numbers of activated glial cells, secreting free radicals and cytotoxic cytokines, subsequently causing neuronal damage. In order to investigate the anti-inflammatory activity of Longvida® Optimised Curcumin (LC), we fed 500 ppm of LC to 2-month-old wild type and GFAP-IL6 mice for 6 months. LC feeding led to a significant reduction in the number of Iba-1+ microglia by 26% in the hippocampus and by 48% in the cerebellum, GFAP+ astrocytes by 30%, and TSPO+ cells by 24% in the hippocampus and by 31% in the cerebellum of the GFAP-IL6 mice.
A sensitive LC-MS assay using derivatization with boron trifluoride to quantify curcuminoids in biological samples.
Yoon AJ et al.
Analyt Biochem. 2020. 596: 113636. ISSN: 003-2697
A procedure is described to measure curcumin (C), demethoxycurcumin (DMC), bisdemethoxycurcumin (BDMC), tetrahydrocurcumim (TC) and their glucuronidated metabolites (CG, DMCG, and BDMCG) in plasma, brain, liver and tumor samples. The procedure involves converting the analytes to their boron difluoride derivatives and analyzing them by combined liquid chromatography coupled to an ion trap mass spectrometer operating in the negative ion MSⁿ scan mode.
An exploratory analysis of changes in mental wellbeing following curcumin and fish oil supplementation in middle-aged and older adults.
Kuszewski JC et al.
Nutrients. 2020. 12(10): 2902. doi: 10.3390/nu12102902
Curcumin has previously been shown to enhance mood in non-depressed older adults. However, observed benefits were limited to short-term supplementation (4 weeks). In a 16 week randomized, double-blind, placebo-controlled, 2 × 2 factorial design trial, we supplemented overweight or obese non-depressed adults (50–80 years) with curcumin (160 mg/day), fish oil (2000 mg docosahexaenoic acid +400 mg eicosapentaenoic acid/day), or a combination of both.
Effects of fish oil and curcumin supplementation on cerebrovascular function in older adults: A randomized controlled trial.
Kuszewski JC et al.
Nut Metab Cardiovasc Dis. 30 Dec 2019. 30(4): 625-633. doi: 10.1016/j.numecd.2019.12.010
Curcumin has previously been shown to enhance mood in non-depressed older adults. However, observed benefits were limited to short-term supplementation (4 weeks). In a 16 week randomized, double-blind, placebo-controlled, 2 × 2 factorial design trial, we supplemented overweight or obese non-depressed adults (50–80 years) with curcumin (160 mg/day), fish oil (2000 mg docosahexaenoic acid +400 mg eicosapentaenoic acid/day), or a combination of both.
Combination treatment of berberine and solid lipid curcumin particles increased cell death and inhibited PI3K/Akt/mTOR pathway of human cultured glioblastoma cells more effectively than did individual treatments.
Maiti P et al.
PLoS ONE. 16 Dec 2019. 14(12): 1-24. doi. 10.1371/journal.pone.0225660
The cytoprotective benefits of a turmeric, quercetin, and rosemary blend through activation of the oxidative stress pathway.
Rajgopal A et al.
Pharmacognosy Magazine. 28 Nov 2019. 15(66): 449-454. doi: 10.4103/pm.pm_556_18
An imbalance between oxidative and reductive processes within cells can result in oxidative stress leading to a decrease in cellular survival. Use of natural products with antioxidant properties may reduce this oxidative stress.
Does acute improvement in muscle recovery with curcumin supplementation translate to long-term training?
McFarlin BK et al.
J Sci Sport Exer. 2019 Oct 30. EPub 2019 Nov 26. pp 1-5. doi: 10.1007/s42978-019-00045-1
A highly bioavailable curcumin extract improves neurocognitive function and mood in healthy older people: A 12-week randomized, double-blind, placebo-controlled trial (OR32-05-19).
Scholey A et al.
Current Dev Nut. 2019 Jun. Poster Presentation. Volume 3(Issue Supplement 1): nzz052.OR32–05–19. doi: 10.1093/cdn/nzz052.OR32-05-19
Previously, researchers at Swinburne University showed significant improvements in measures of memory, attention, fatigue, stress, and mood (Cox KH et al, 2015). This trial was a follow up to the results previously seen in 1 and 3 hrs and in 4-weeks. The results of this second trial further confirm that a single daily dose of 400mg of Longvida improves aspects of mood and working memory in healthy older adults, with measures at 12-weeks.
Effect of an oral supplement containing curcumin extract (Longvida®) on lameness due to osteoarthritis and gastric ulcer soreness.
Andrews FM et al
Poster Presentation 2019
See 2022 publication for full reference.
Curcumin and solid lipid curcumin particles induce autophagy, but inhibit mitophagy and the PI3K-Akt/mTOR pathway in cultured glioblastoma cells.
Maiti P et al.
Int J Mol Sci. 18 Jan 2019. 20(2): 399. doi: 10.3390/ijms20020399
Autophagy and the (PI3K-Akt/mTOR) signaling pathway play significant roles in glioblastoma multiforme (GBM) cell death and survival. Curcumin (Cur) has been reported to prevent several cancers, including GBM. However, the poor solubility and limited bioavailability of natural Cur limits its application in preventing GBM growth.
The anti-inflammatory potential of curcumin preparations on activated glial cell numbers and morphology in the GFAP-IL6 mouse brain.
Gyengesi E et al.
Poster presentation in: 2019 Neuroscience Meeting Planner. Chicago, IL; 2019: Program No. 539.04.
Curcumin supplementation alters inflammatory cytokines following exercise.
McFarlin BK et al.
Poster presentation. Med Sci Sport Exerc. 2019. 51: 90.
The study evaluated different doses and their impact post-exercise recovery and inflammation through perceived muscle soreness, inflammatory biomarkers, and muscle injury. 400mg and 1000mg/day doses were associated with a reduction in inflammatory signals and creatine kinase. Researchers indicated that the 1000mg/day dose was most effective at reducing subjective soreness and whole-body inflammation.
Dose-dependent effectiveness of optimized curcumin supplementation to alter inflammation following exertion-induced skeletal muscle injury.
McFarlin BK et al.
Poster presentation in: Autumn Immunology Conference. Chicago, IL. 2019.
The study evaluated different doses and their impact post-exercise recovery and inflammation through perceived muscle soreness, inflammatory biomarkers, and muscle injury. 400mg and 1000mg/day doses were associated with a reduction in inflammatory signals and creatine kinase. Researchers indicated that the 1000mg/day dose was most effective at reducing subjective soreness and whole-body inflammation.
Effects of composite supplement containing curcumin, ferulic acid, and soybean-derived phosphatidylserine on cognitive function in healthy middle-aged and senior adults – A randomized, double-blind, placebo-controlled, parallel-group study.
Kawamoto K et al.
Japanese Pharmacol Ther. 2019. 47: 1253-68.
Longvida®, in a blend, offered tangible health benefits to cognitive function including memory, attention, and judgement in healthy middle-aged and senior adults, with significant improvements to memory and attention in the Longvida group compared to placebo after 20 weeks. Longvida, as a blend, exhibited no side effects during the study.
The anti-inflammatory potential of curcumin preparations on activated glial cell numbers and morphology in the GFAP-IL6 mouse brain.
Gyengesi E.
Poster Presentation in: Neuroscience. Chicago, IL. 2019. Session 539 (Abstract 9909).
Long-term supplementation with Longvida offers support to neuroinflammatory biomarkers associated with neural inflammation through decreases in microglial activation.
