Longvida® Research
Longvida® Research
Don’t see what you’re looking for? All additional research is categorized under supportive research.
Use of curcumin with tyrosine kinase inhibitors in EGFR-mutant non-small cell lung: A phase I prospective cohort trial.
Esfahani K et al.
J Alter Comp Integr Med. 2021 Nov 02. 7: 201. doi: 10.24966/ACIM-7562/100201
Curcumin has been shown to modulate many of the known pathways causing resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors (EGFR-TKIs) in pre-clinical studies.
Effect of an oral supplement containing curcumin extract (Longvida®) on lameness due to OA and gastric ulcer scores.
Andrews FM et al.
Equine Vet Educ. 2022. 1-12. doi: 10.1111/eve.13616
Effects of nutrition on cognitive function in adults with or without cognitive impairment: A systematic review of randomized controlled clinical trials.
Gutierrez L et al.
Nutrients. 22 Oct 2021. 13(11): 3728. doi: 10.3390/nu13113728
Age-related alterations to working memory and to pyramidal neurons in the prefrontal cortex of rhesus monkeys begin in early middle-age and are partially ameliorated by dietary curcumin.
Chang W et al.
Neurobiol Aging. 16 Sept 2021. doi: 10.1016/j.neurobiolaging.2021.09.012
We compared the properties of L3 pyramidal neurons from the LPFC of behaviorally characterized rhesus monkeys over the adult lifespan using whole-cell patch clamp recordings and neuronal reconstructions.
Retinal amyloid imaging for screening AD.
Tadokoro K et al.
J Alz Dis. Aug 2021. 83(2): 927-934. doi: 10.3233/JAD-210327
The present noninvasive in vivo detection of retinal amyloid deposition is useful for screening patients.
Short term, oral supplementation with optimized curcumin does not impair performance improvements associated with high intensity interval training.
Kisiolek JN et al.
J Diet Suppl. 11Jun 2021. 0(0): pp 1-14. 2021, doi: 10.1080/19390211.2021.1936335.
Curcumin may improve athletic performance through a reduction in inflammation following exercise and improve mental states of well-being. The purpose of this investigation was to explore the effects of a 14 day HIIT intervention and oral supplementation with Longvida® optimized curcumin on athletic performance, lactate response, and well-being.
Feasibility study for detection of retinal amyloid in clinical trials: The anti‐amyloid treatment in asymptomatic AD (A4) trial.
Ngolab J et al.
Alz Dement. 25 May 2021. 13(1): e12199. doi: 10.1002/dad2.12199
Longvida was used to quantify amyloid plaques in the retina of patients. Longvida was safe and efficacious.
Preservation of dendritic spine morphology and postsynaptic signaling markers after treatment with solid lipid curcumin particles in the 5xFAD mouse model of AD amyloidosis.
Maiti P et al.
Alz Res Ther. 08 Feb 2021. 13(37): 1-22. doi: 10.1186/s13195-021-00769-9
Synaptic failure is one of the principal events associated with cognitive dysfunction in Alzheimer’s disease (AD). Preservation of existing synapses and prevention of synaptic loss are promising strategies to preserve cognitive function in AD patients. As a potent natural anti-oxidant, anti-amyloid, and anti-inflammatory polyphenol, curcumin (Cur) shows great promise as a therapy for AD.
Curcumin supplementation improves reversal learning in middle aged rhesus monkeys.
Uprety A et al.
Behav Neurosci. 2021. No BNE-2021-0237R2
Sectoral segmentation of retinal amyloid imaging in subjects with cognitive decline.
Dumitrascu OM et al.
Alz Dement: Diagno Assess Dise Monitor. 2020 Sept 28. 12(1): 1-10. doi: 10.1002/dad2.12109
Alzheimer's disease (AD) is a devastating neurodegenerative disorder and the most prevalent form of dementia, associated with enormous social and public health challenges. Considerable evidence supports that quantitative imaging of biofluid biomarkers of AD pathology, amyloid beta (Aβ), tau, and neurodegeneration, may be useful predictors of subsequent cognitive decline. Aβ is a pathological hallmark of AD, the target of disease-modifying therapies,3 and useful in discriminating AD from other neuropathologies.
Fish oil supplementation reduces osteoarthritis-specific pain in older adults with overweight/obesity.
Kuszewski JC et al.
Rheumatol Adv Pract. 2020 Jul 23. 4(2): 1-9. doi: 10.1093/rap/rkaa036
OA is a leading cause of chronic pain and disability. Next to inflammation, vascular pathology has been hypothesized to play a role in its aetiology and progression. Owing to side effects and the low efficacy of pharmacological treatments, dietary supplements are popular as alternative treatments, but evidence of efficacy is limited. We tested whether fish oil and curcumin supplementation can reduce chronic pain and OA burden in older adults.
Further evidence of benefits to mood and working memory from lipidated curcumin [Longvida] in healthy older people: A 12-week, double-blind, placebo-controlled, partial replication study.
Cox KHM et al.
Nutrients. 2020 Jun 04. 12(6): 1678. doi: 10.3390/nu12061678
A partial replication study by researchers at Swinburne University reveals Longvida® improves aspects of mood, memory, and working memory in a healthy older cohort. The pattern of results is consistent with improvements in hippocampal function and may hold promise for alleviating cognitive decline in some populations. This study examined a similar population with slightly elevated cognitive abilities, while eliciting similar results to the first clinical published in 2014 - see Cox KH et al, 2014.
Effects of fish oil and curcumin supplementation on cerebrovascular function in older adults: A randomized controlled trial.
Kuszewski JC et al.
Nutr Metab Cardiovasc Dis. 2020 Apr 12. 30(4): 625-633. EPub 2019 Dec 30. doi: 1016/j.numecd.2019.12.010
Longvida®, in combindation with fish oil, offered tangible health benefits with significant increase in HDL cholesterol (p=0.001) and attenuated a reduction in triglycerides, which is intriguing since triglycerides and HDLs are usually inversely related. Overall, the addition of Longvida to fish oil showed no contraindications, and that Longvida taken with fish oil does not appear to hinder the ability of Longvida to offer tangible health benefits. No serious adverse events were observed.
Effects of Solid, Lipid Curcumin Particles on alcohol metabolism – An expiatory and a randomized, double-blind, placebo-controlled, parallel-group crossover study.
Machida N et al.
Jpn Pharmacol Ther. 2020 Apr. 48(5): 867-873.
This study further provides evidence that Longvda curcumin is safe and efficacious. Previously examined in 2014, and recently published, researchers report reduced side effects typically associated with alcohol consumption and suggest that Longvida may offer liver health support through the acceleration of ethanol and acetaldehyde metabolism.
Exploring the relationship between optimized bioavailable curcumin and performance after an intensified training program.
Kisiolek JN et al.
Poster presentation. FASEB J. 2020 Apr. 34(S1): 1. doi: 10.1096/fasebj.2020.34.s1.05415
The purpose of this double blind, randomized, study was to determine the effects of Longvida® Optimized Curcumin on time trial performance time as well as the inflammatory mediator C-reactive protein (CRP) after 2 weeks of an intensified training program.
Don’t see what you’re looking for? All additional research is categorized under supportive research.
Use of curcumin with tyrosine kinase inhibitors in EGFR-mutant non-small cell lung: A phase I prospective cohort trial.
Esfahani K et al.
J Alter Comp Integr Med. 2021 Nov 02. 7: 201. doi: 10.24966/ACIM-7562/100201
Curcumin has been shown to modulate many of the known pathways causing resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors (EGFR-TKIs) in pre-clinical studies.
Effect of an oral supplement containing curcumin extract (Longvida®) on lameness due to OA and gastric ulcer scores.
Andrews FM et al.
Equine Vet Educ. 2022. 1-12. doi: 10.1111/eve.13616
Effects of nutrition on cognitive function in adults with or without cognitive impairment: A systematic review of randomized controlled clinical trials.
Gutierrez L et al.
Nutrients. 22 Oct 2021. 13(11): 3728. doi: 10.3390/nu13113728
Age-related alterations to working memory and to pyramidal neurons in the prefrontal cortex of rhesus monkeys begin in early middle-age and are partially ameliorated by dietary curcumin.
Chang W et al.
Neurobiol Aging. 16 Sept 2021. doi: 10.1016/j.neurobiolaging.2021.09.012
We compared the properties of L3 pyramidal neurons from the LPFC of behaviorally characterized rhesus monkeys over the adult lifespan using whole-cell patch clamp recordings and neuronal reconstructions.
Retinal amyloid imaging for screening AD.
Tadokoro K et al.
J Alz Dis. Aug 2021. 83(2): 927-934. doi: 10.3233/JAD-210327
The present noninvasive in vivo detection of retinal amyloid deposition is useful for screening patients.
Short term, oral supplementation with optimized curcumin does not impair performance improvements associated with high intensity interval training.
Kisiolek JN et al.
J Diet Suppl. 11Jun 2021. 0(0): pp 1-14. 2021, doi: 10.1080/19390211.2021.1936335.
Curcumin may improve athletic performance through a reduction in inflammation following exercise and improve mental states of well-being. The purpose of this investigation was to explore the effects of a 14 day HIIT intervention and oral supplementation with Longvida® optimized curcumin on athletic performance, lactate response, and well-being.
Feasibility study for detection of retinal amyloid in clinical trials: The anti‐amyloid treatment in asymptomatic AD (A4) trial.
Ngolab J et al.
Alz Dement. 25 May 2021. 13(1): e12199. doi: 10.1002/dad2.12199
Longvida was used to quantify amyloid plaques in the retina of patients. Longvida was safe and efficacious.
Preservation of dendritic spine morphology and postsynaptic signaling markers after treatment with solid lipid curcumin particles in the 5xFAD mouse model of AD amyloidosis.
Maiti P et al.
Alz Res Ther. 08 Feb 2021. 13(37): 1-22. doi: 10.1186/s13195-021-00769-9
Synaptic failure is one of the principal events associated with cognitive dysfunction in Alzheimer’s disease (AD). Preservation of existing synapses and prevention of synaptic loss are promising strategies to preserve cognitive function in AD patients. As a potent natural anti-oxidant, anti-amyloid, and anti-inflammatory polyphenol, curcumin (Cur) shows great promise as a therapy for AD.
Curcumin supplementation improves reversal learning in middle aged rhesus monkeys.
Uprety A et al.
Behav Neurosci. 2021. No BNE-2021-0237R2
Sectoral segmentation of retinal amyloid imaging in subjects with cognitive decline.
Dumitrascu OM et al.
Alz Dement: Diagno Assess Dise Monitor. 2020 Sept 28. 12(1): 1-10. doi: 10.1002/dad2.12109
Alzheimer's disease (AD) is a devastating neurodegenerative disorder and the most prevalent form of dementia, associated with enormous social and public health challenges. Considerable evidence supports that quantitative imaging of biofluid biomarkers of AD pathology, amyloid beta (Aβ), tau, and neurodegeneration, may be useful predictors of subsequent cognitive decline. Aβ is a pathological hallmark of AD, the target of disease-modifying therapies,3 and useful in discriminating AD from other neuropathologies.
Fish oil supplementation reduces osteoarthritis-specific pain in older adults with overweight/obesity.
Kuszewski JC et al.
Rheumatol Adv Pract. 2020 Jul 23. 4(2): 1-9. doi: 10.1093/rap/rkaa036
OA is a leading cause of chronic pain and disability. Next to inflammation, vascular pathology has been hypothesized to play a role in its aetiology and progression. Owing to side effects and the low efficacy of pharmacological treatments, dietary supplements are popular as alternative treatments, but evidence of efficacy is limited. We tested whether fish oil and curcumin supplementation can reduce chronic pain and OA burden in older adults.
Further evidence of benefits to mood and working memory from lipidated curcumin [Longvida] in healthy older people: A 12-week, double-blind, placebo-controlled, partial replication study.
Cox KHM et al.
Nutrients. 2020 Jun 04. 12(6): 1678. doi: 10.3390/nu12061678
A partial replication study by researchers at Swinburne University reveals Longvida® improves aspects of mood, memory, and working memory in a healthy older cohort. The pattern of results is consistent with improvements in hippocampal function and may hold promise for alleviating cognitive decline in some populations. This study examined a similar population with slightly elevated cognitive abilities, while eliciting similar results to the first clinical published in 2014 - see Cox KH et al, 2014.
Effects of fish oil and curcumin supplementation on cerebrovascular function in older adults: A randomized controlled trial.
Kuszewski JC et al.
Nutr Metab Cardiovasc Dis. 2020 Apr 12. 30(4): 625-633. EPub 2019 Dec 30. doi: 1016/j.numecd.2019.12.010
Longvida®, in combindation with fish oil, offered tangible health benefits with significant increase in HDL cholesterol (p=0.001) and attenuated a reduction in triglycerides, which is intriguing since triglycerides and HDLs are usually inversely related. Overall, the addition of Longvida to fish oil showed no contraindications, and that Longvida taken with fish oil does not appear to hinder the ability of Longvida to offer tangible health benefits. No serious adverse events were observed.
Effects of Solid, Lipid Curcumin Particles on alcohol metabolism – An expiatory and a randomized, double-blind, placebo-controlled, parallel-group crossover study.
Machida N et al.
Jpn Pharmacol Ther. 2020 Apr. 48(5): 867-873.
This study further provides evidence that Longvda curcumin is safe and efficacious. Previously examined in 2014, and recently published, researchers report reduced side effects typically associated with alcohol consumption and suggest that Longvida may offer liver health support through the acceleration of ethanol and acetaldehyde metabolism.
Exploring the relationship between optimized bioavailable curcumin and performance after an intensified training program.
Kisiolek JN et al.
Poster presentation. FASEB J. 2020 Apr. 34(S1): 1. doi: 10.1096/fasebj.2020.34.s1.05415
The purpose of this double blind, randomized, study was to determine the effects of Longvida® Optimized Curcumin on time trial performance time as well as the inflammatory mediator C-reactive protein (CRP) after 2 weeks of an intensified training program.
