New Research: Witholytin® Ashwagandha Extract Mitigates Perceived Stress And Fatigue In Men & Women

New Research: Witholytin® Ashwagandha Extract Mitigates Perceived Stress And Fatigue In Men & Women

A new study examining Witholytin®, a proprietary Withania somnifera extract standardized to 1.5% total withanolides, evaluated safety and impacts to perceived stress and fatigue in 111 men and women (40-75yrs) experiencing low energy and moderate-to-high perceived stress over 12-weeks. The study used a low daily dose of 200mg Witholytin® twice a day, designed to evaluate Witholytin’s adaptogenic potential; promoting homeostasis and balance in the body.1

Researchers explained that supplementation with Witholytin® ashwagandha was associated with a statistically significant 45.81% reduction in the Chalder Fatigue Scale (CFS) total score & a 38.59% reduction in stress levels based on the Perceived Stress Scale compared to baseline at 12-weeks. This suggests that Witholytin® may support an adaptogenic approach to combat fatigue, regain vitality, and promote homeostasis and balance. Further, researchers claim Witholytin® exhibited substantial energy bolstering effects in overweight middle-to-older age adults who are experiencing high stress and fatigue.1

A sub-analysis was performed to examine hormone biomarkers in both men and women.1 In the men taking Witholytin® ashwagandha, there was a significant 12.87% increase in blood concentrations of free testosterone (p = 0.048) and luteinizing hormone (p= 0.002) compared to the placebo group.1 However, for women, there were no statistically significant blood markers and hormone concentrations. There was a trend suggesting a between-group difference in change in estradiol concentrations over time (p = 0.137).1 In the ashwagandha group, there was a statistically significant increase (59.72%) in estradiol concentrations from baseline to week 12 (p = 0.029) and a non-significant reduction of 1.49% in the placebo group (0.955).1 “We were very excited to see these hormone biomarkers,” explained Kristen Marshall, Digital Marketing manager, Verdure Sciences®. Marshall expanded, “many formulations targeting men and women have prioritized adaptogens, as have fortified functional foods and beverages, and Witholytin® is well suited to grow in these areas with this research.”

“We are excited to have this new publication join the evidence in support of Witholytin® and our mounting body of evidence for ashwagandha extract standardization to USP methodology,” explains Verdure Sciences’ Executive Vice President, Sonya Cropper. Cropper continued, “tremendous interest continues to build for ashwagandha, adaptogens, fatigue, energy, and mental vitality.”†

† These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

 

Read More:

  1. https://www.nutraceuticalsworld.com/contents/view_breaking-news/2023-10-13/ashwagandha-extract-linked-to-reductions-in-perceived-stress-and-fatigue
  2. https://www.nutraingredients-usa.com/Article/2023/10/17/verdure-s-ashwagandha-may-offer-anti-fatigue-benefits
  3. https://www.nutritionaloutlook.com/view/ashwagandha-supports-stress-and-fatigue-in-recent-study
  4. https://www.nutraceuticalsworld.com/contents/view_breaking-news/2024-01-29/ashwagandha-extract-may-offer-anti-fatigue-benefits-to-overweight-subjects/
  5. https://nutraceuticalbusinessreview.com/Verdure-Sciences-human-clinical-study-ashwagandha
  6. https://www.nutritionaloutlook.com/view/proprietary-ashwagandha-root-extract-supports-stress-and-fatigue-in-recent-study
  7. https://www.nutritioninsight.com/news/verdure-sciences-research-on-ashwagandha-shows-major-energy-boost-and-stress-reduction.html

 

References:

  1. Smith SJ et al. Exploring the efficacy and safety of a novel standardized ashwagandha (Withania somnifera) root extract (Witholytin®) in adults experiencing high stress and fatigue in a randomized, double-blind, placebo-controlled trial. J Psychopharmacol. Epub 2023 Sep 23. 0(0). doi: 10.1177/02698811231200023
  2. https://vs-corp.com/research/ashwagandha/
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A new study examining Witholytin®, a proprietary Withania somnifera extract standardized to 1.5% total withanolides, evaluated safety and impacts to perceived stress and fatigue in 111 men and women (40-75yrs) experiencing low energy and moderate-to-high perceived stress over 12-weeks. The study used a low daily dose of 200mg Witholytin® twice a day, designed to evaluate Witholytin’s adaptogenic potential; promoting homeostasis and balance in the body.1

Researchers explained that supplementation with Witholytin® ashwagandha was associated with a statistically significant 45.81% reduction in the Chalder Fatigue Scale (CFS) total score & a 38.59% reduction in stress levels based on the Perceived Stress Scale compared to baseline at 12-weeks. This suggests that Witholytin® may support an adaptogenic approach to combat fatigue, regain vitality, and promote homeostasis and balance. Further, researchers claim Witholytin® exhibited substantial energy bolstering effects in overweight middle-to-older age adults who are experiencing high stress and fatigue.1

A sub-analysis was performed to examine hormone biomarkers in both men and women.1 In the men taking Witholytin® ashwagandha, there was a significant 12.87% increase in blood concentrations of free testosterone (p = 0.048) and luteinizing hormone (p= 0.002) compared to the placebo group.1 However, for women, there were no statistically significant blood markers and hormone concentrations. There was a trend suggesting a between-group difference in change in estradiol concentrations over time (p = 0.137).1 In the ashwagandha group, there was a statistically significant increase (59.72%) in estradiol concentrations from baseline to week 12 (p = 0.029) and a non-significant reduction of 1.49% in the placebo group (0.955).1 “We were very excited to see these hormone biomarkers,” explained Kristen Marshall, Digital Marketing manager, Verdure Sciences®. Marshall expanded, “many formulations targeting men and women have prioritized adaptogens, as have fortified functional foods and beverages, and Witholytin® is well suited to grow in these areas with this research.”

“We are excited to have this new publication join the evidence in support of Witholytin® and our mounting body of evidence for ashwagandha extract standardization to USP methodology,” explains Verdure Sciences’ Executive Vice President, Sonya Cropper. Cropper continued, “tremendous interest continues to build for ashwagandha, adaptogens, fatigue, energy, and mental vitality.”†

† These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

 

Read More:

  1. https://www.nutraceuticalsworld.com/contents/view_breaking-news/2023-10-13/ashwagandha-extract-linked-to-reductions-in-perceived-stress-and-fatigue
  2. https://www.nutraingredients-usa.com/Article/2023/10/17/verdure-s-ashwagandha-may-offer-anti-fatigue-benefits
  3. https://www.nutritionaloutlook.com/view/ashwagandha-supports-stress-and-fatigue-in-recent-study
  4. https://www.nutraceuticalsworld.com/contents/view_breaking-news/2024-01-29/ashwagandha-extract-may-offer-anti-fatigue-benefits-to-overweight-subjects/
  5. https://nutraceuticalbusinessreview.com/Verdure-Sciences-human-clinical-study-ashwagandha
  6. https://www.nutritionaloutlook.com/view/proprietary-ashwagandha-root-extract-supports-stress-and-fatigue-in-recent-study
  7. https://www.nutritioninsight.com/news/verdure-sciences-research-on-ashwagandha-shows-major-energy-boost-and-stress-reduction.html

 

References:

  1. Smith SJ et al. Exploring the efficacy and safety of a novel standardized ashwagandha (Withania somnifera) root extract (Witholytin®) in adults experiencing high stress and fatigue in a randomized, double-blind, placebo-controlled trial. J Psychopharmacol. Epub 2023 Sep 23. 0(0). doi: 10.1177/02698811231200023
  2. https://vs-corp.com/research/ashwagandha/

About Verdure Sciences®:

Verdure Sciences manages ingredient innovation throughout the integration of supply network, production, and research platforms. With an expanding pipeline of proprietary, standardized botanical ingredients supported by pharmacokinetic, pharmacodynamic, and clinical research profiles, we work toward our unified vision to offer safe, effective ingredient solutions. Verdure Sciences® is a registered trademark of Verdure Sciences®, Inc.

For our most current patent and trademark information, please visit: https://vs-corp.com/ip/ | https://vs-corp.com for more information

About Verdure Sciences®:

Verdure Sciences manages ingredient innovation throughout the integration of supply network, production, and research platforms. With an expanding pipeline of proprietary, standardized botanical ingredients supported by pharmacokinetic, pharmacodynamic, and clinical research profiles, we work toward our unified vision to offer safe, effective ingredient solutions. Verdure Sciences® is a registered trademark of Verdure Sciences®, Inc.

For our most current patent and trademark information, please visit: https://vs-corp.com/ip/ | https://vs-corp.com for more information