Pomella® Named Finalist for Nutrition Research Project Award

Pomella® Named Finalist for Nutrition Research Project Award

We’re proud to announce “Prospective, randomized, double-blind, placebo-controlled study of a standardized oral pomegranate extract [Pomella®] on the gut microbiome and short-chain fatty acids” has been honored as a finalist for the Nutrition Research Project category at the 2024 NutraIngredients-USA Awards, highlighting its role in advancing the field of nutrition through groundbreaking research. The Nutrition Research Project category rewards the most innovative and impactful nutrition research projects pushing the boundaries of nutritional science, explains the NutraIngredients Awards website.

 

2024-nutraingredients-usa-award-finalist-pomella-1400x790

 

The research project, a four-week, double-blind, placebo-controlled, randomized clinical trial, evaluated 250mg/day Pomella®, a proprietary Punica granatum extract, in healthy men and women 25-55yrs (n=18, predominantly women) for beneficial effects on the gut microbiome, circulating short-chain fatty acids, and gut-microbial derived ellagitannin metabolites, namely urolithins, using whole genome sequencing for gut microbial analysis.

Researchers explained, “our study revealed that the oral supplementation of Pomella®, leads to significant shifts in the gut microbiota, increases the circulating plasma levels of short-chain fatty acids such as propionate and acetate, and increases the plasma levels of urolithin A levels.”1 Further, “Our results demonstrate a significant increase in the abundance of multiple short-chain producing bacteria in the gut microbiome of the [Pomella® extract] group along with an increase in the circulating acetate and propionate levels.”1

In addition to these highly anticipated results, which lead researcher, Dr. Raja Sivamani, previously reported on in a comprehensive webinar2, this research project highlighted impressive results tangent to metabolic health, women’s health, mitochondrial support and cellular health. Pomella® augmented the genes for the synthesis of several key amino acids and supported a catabolic state (energy-yielding metabolism) for the TCA cycle.1 The TCA cycle, tricarboxylic acid cycle, also known as the Krebs’ cycle or citric acid cycle, is the major energy-yielding metabolic pathway in cells which produces adenosine triphosphate (ATP). This has potential to impact mitochondrial and cellular health and adds mechanistic insight into previously reported findings supporting cardio-metabolic health.3-4

“The recognition of Pomella® as a finalist for the Nutrition Research Project serves as a testament to its impact on health and nutrition.”, said Kristen Marshall, Digital Marketing Manager at Verdure Sciences®. “This research project joins mounting evidence supporting Pomella® as an efficacious pomegranate extract and has contributed to the growing body of evidence supporting pomegranate polyphenols.”

“We extend our deepest gratitude to our research team, the lead researchers of this research project, and to the distinguished panel of judges at NutraIngredients-USA for selecting this research project as a finalist”, said Antonio King, Digital Marketing Specialist at Verdure Sciences®. “We also would like to congratulate the outstanding shortlist of finalists paving the way for nutritional science at this year’s NutraIngredients-USA Awards”,

Winners for the NutraIngredients-USA Awards will be announced on Monday, July 15, 2024 during an awards presentation at NutraIngredients-USA’s Chicago HQ.

 

Read More

 

References

  1. Sivamani RK et al. Prospective, randomized, double-blind, placebo-conteolled study of a standardized oral pomegranate extract on the gut microbiome and short-chain fatty acids. Foods. 2023 Dec 19. 13(1): 15pgs. doi: 10.3390/foods13010015
  2. Sivamani RK, MD, MS, AP. (2022 Sep 15). NutraIngredients-USA: Beauty from within clinical study finds Pomella® extract supports skin health benefits and associated influence on the gut-skin axis (webinar). Retrieved 2023 Dec 20 from https://vs-corp.com/resources/webinars/pomella-pomegranate-extract-beauty-from-within-with-dr-raja-sivamani-long-version/
  3. Goyal R et al. An antioxidative effect of Punica granatum (pomegranate) on biochemical parameters in patients with MI: A double-blind placebo controlled trial. Eur J Biomed Pharm Sci. 2016. 3(5): 662-667
  4. Goyal R et al. Antioxidative effect of Punica granatum (pomegranate) on biochemical parameters in patients with T2D and MI: A double-blind placebo controlled trial. Int J Adv res. 2016. 4(5): 857-864

We’re proud to announce “Prospective, randomized, double-blind, placebo-controlled study of a standardized oral pomegranate extract [Pomella®] on the gut microbiome and short-chain fatty acids” has been honored as a finalist for the Nutrition Research Project category at the 2024 NutraIngredients-USA Awards, highlighting its role in advancing the field of nutrition through groundbreaking research. The Nutrition Research Project category rewards the most innovative and impactful nutrition research projects pushing the boundaries of nutritional science, explains the NutraIngredients Awards website.

 

2024-nutraingredients-usa-award-finalist-pomella-1400x790

 

The research project, a four-week, double-blind, placebo-controlled, randomized clinical trial, evaluated 250mg/day Pomella®, a proprietary Punica granatum extract, in healthy men and women 25-55yrs (n=18, predominantly women) for beneficial effects on the gut microbiome, circulating short-chain fatty acids, and gut-microbial derived ellagitannin metabolites, namely urolithins, using whole genome sequencing for gut microbial analysis.

Researchers explained, “our study revealed that the oral supplementation of Pomella®, leads to significant shifts in the gut microbiota, increases the circulating plasma levels of short-chain fatty acids such as propionate and acetate, and increases the plasma levels of urolithin A levels.”1 Further, “Our results demonstrate a significant increase in the abundance of multiple short-chain producing bacteria in the gut microbiome of the [Pomella® extract] group along with an increase in the circulating acetate and propionate levels.”1

In addition to these highly anticipated results, which lead researcher, Dr. Raja Sivamani, previously reported on in a comprehensive webinar2, this research project highlighted impressive results tangent to metabolic health, women’s health, mitochondrial support and cellular health. Pomella® augmented the genes for the synthesis of several key amino acids and supported a catabolic state (energy-yielding metabolism) for the TCA cycle.1 The TCA cycle, tricarboxylic acid cycle, also known as the Krebs’ cycle or citric acid cycle, is the major energy-yielding metabolic pathway in cells which produces adenosine triphosphate (ATP). This has potential to impact mitochondrial and cellular health and adds mechanistic insight into previously reported findings supporting cardio-metabolic health.3-4

“The recognition of Pomella® as a finalist for the Nutrition Research Project serves as a testament to its impact on health and nutrition.”, said Kristen Marshall, Digital Marketing Manager at Verdure Sciences®. “This research project joins mounting evidence supporting Pomella® as an efficacious pomegranate extract and has contributed to the growing body of evidence supporting pomegranate polyphenols.”

“We extend our deepest gratitude to our research team, the lead researchers of this research project, and to the distinguished panel of judges at NutraIngredients-USA for selecting this research project as a finalist”, said Antonio King, Digital Marketing Specialist at Verdure Sciences®. “We also would like to congratulate the outstanding shortlist of finalists paving the way for nutritional science at this year’s NutraIngredients-USA Awards”,

Winners for the NutraIngredients-USA Awards will be announced on Monday, July 15, 2024 during an awards presentation at NutraIngredients-USA’s Chicago HQ.

 

Read More

 

References

  1. Sivamani RK et al. Prospective, randomized, double-blind, placebo-conteolled study of a standardized oral pomegranate extract on the gut microbiome and short-chain fatty acids. Foods. 2023 Dec 19. 13(1): 15pgs. doi: 10.3390/foods13010015
  2. Sivamani RK, MD, MS, AP. (2022 Sep 15). NutraIngredients-USA: Beauty from within clinical study finds Pomella® extract supports skin health benefits and associated influence on the gut-skin axis (webinar). Retrieved 2023 Dec 20 from https://vs-corp.com/resources/webinars/pomella-pomegranate-extract-beauty-from-within-with-dr-raja-sivamani-long-version/
  3. Goyal R et al. An antioxidative effect of Punica granatum (pomegranate) on biochemical parameters in patients with MI: A double-blind placebo controlled trial. Eur J Biomed Pharm Sci. 2016. 3(5): 662-667
  4. Goyal R et al. Antioxidative effect of Punica granatum (pomegranate) on biochemical parameters in patients with T2D and MI: A double-blind placebo controlled trial. Int J Adv res. 2016. 4(5): 857-864

About Verdure Sciences®:

Verdure Sciences manages ingredient innovation throughout the integration of supply network, production, and research platforms. With an expanding pipeline of proprietary, standardized botanical ingredients supported by pharmacokinetic, pharmacodynamic, and clinical research profiles, we work toward our unified vision to offer safe, effective ingredient solutions. Verdure Sciences® is a registered trademark of Verdure Sciences®, Inc.

For our most current patent and trademark information, please visit: https://vs-corp.com/ip/ | https://vs-corp.com for more information

About Verdure Sciences®:

Verdure Sciences manages ingredient innovation throughout the integration of supply network, production, and research platforms. With an expanding pipeline of proprietary, standardized botanical ingredients supported by pharmacokinetic, pharmacodynamic, and clinical research profiles, we work toward our unified vision to offer safe, effective ingredient solutions. Verdure Sciences® is a registered trademark of Verdure Sciences®, Inc.

For our most current patent and trademark information, please visit: https://vs-corp.com/ip/ | https://vs-corp.com for more information