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Please note that the physiological activity of the ingredient(s) described herein is supported by the referenced clinical trial reports. Marketers of finished products containing the ingredient(s) described herein are responsible for determining whether claims made for such products are lawful and in compliance with the laws of the country in which they will market the products.



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Pharmacokinetics of solid lipid Boswellia serrata particles [WokVel® SLP] in healthy subjects.

Kulkarni PD et al.
Drug Metabol Personal Ther. 05 Apr 2021. 0(0). doi: 10.1515/dmdi-2020-0176
The anti-inflammatory activity of Boswellia serrata extracts (BSE) is well known. BSE comprises boswellic acids (BA) such as 3-O-acetyl-11-keto-beta-boswellic acid (AKBA) and 11-keto-boswellic acid (KBA) as major constituents. One of the limitations of BAs is their poor oral bioavailability. The aim of the study was to prepare solid lipid particles of Boswellia serrata extract (SLBSP) to enhance the bioavailability of BAs.

Double-blind trial of solid lipid Boswellia serrata particles (SLBSP) [WokVel® SLP] vs. standardized Boswellia serrata gum extract (BSE) [WokVel®] for OA of knee.

Kulkarni PD et al.
Drug Metabol Personal Ther. 08 Jun 2020. 35(2). doi: 10.1515/dmpt-2020-0104
The present study was planned to investigate the efficacy of SLBSP vs. standardized BSE for symptomatic knee osteoarthritis (OA) treatment. Methods It was a prospective, randomized, double-blind, double-dummy, placebo-controlled, and single-centre clinical trial for symptomatic osteoarthritis of knee.

Development of a neuroprotective potential algorithm for medicinal plants.

Liu W et al.
University of Rhode Island. Neurochem Int. 2016 Sep 29. 100: 164-177.
As part of a strategy to help guide the selection and evaluation of medicinal plant candidates for their neuroprotective potential, researchers at the University of Rhode Island developed a Neuroprotective Potential Algorithm (NPA) by evaluating twenty-three standardized and chemically characterized Ayurvedic medicinal plant extracts in a panel of bioassays targeting oxidative stress, carbonyl stress, protein glycation, amyloid beta (Aβ) fibrillation, acetylcholinesterase (AChE) inhibition, and neuroinflammation.

Comparison of the metabolic stability of solid lipid Boswellia serrata particles [WokVel® SLP] versus plain Boswellia serrata extract [WokVel®] in human hepatocytes (HHL-17).

Gota P et al.
Int J Pharm Chem Biol Sci. 2016. 6(1): 22-27.
In an in vitro study in human hepatocytes HHL-17, WokVel® SLP™ (Solid Lipid Particle) exhibited lesser accumulation of KBA in hepatocytes and low metabolic clearance. With reported extremely low hepatic clearance of AKBA and conferred metabolic stability of KBA in this study, WokVel® SLP™ may have enhanced oral bioavailability of KBA and AKBA compared to WokVel.

Efficacy of solid lipid Boswellia serrata particles (SLBSP) in OA of knee.

Gota P et al.
J Pharm Sci Tech Mgmt. 2015 Jul. 1(2): 70-76.
Patients with osteoarthritis were treated with solid lipid Boswellia serrata particles (SLBSP – WokVel® SLP) capusles for two months. There was significant improvement in pain and function scores of the WOMAC and VAS indices, and the need for rescue analgesics was markedly decreased by 67% during the first month and 76% during the second, compared to baseline.

Prospects of boswellic acids as potential pharmaceutics.

Du Z et al.
Planta Med. 2015. 81(04): 259-271. doi: 10.1055/s-0034-1396313
A comprehensive review on boswellic acids and their potential for clinical applications; bioavailability, different derivatives, and bioavailability enhancement is discussed.