Anti-melanogenic potential of thymoquinone isolated from black cumin (Nigella sativa L) [as Thymocid®] seed oil.
DaSilva N et al.
University of Rhode Island: INBRE Poster Presentation. 2017.
Tyrosinase and tyrosinase-related protein-1 (TRP-1) and TRP-2 plays a major role in melanin synthesis. Supports youthful skin by inhibiting Tyrosinase and melanin production to look skin tone more even. In an in vitro study, TQ’s de-pigmenting ability against B16F10 melanoma cells was not caused by direct inhibition of the tyrosinase enzyme, but by inhibition of tyrosinase processing and maturation in the melanoma cells. This effect is associated with TQ’s ability to down regulate gene and protein expressions of MITF, TYRP-1 and TYRP-2.