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Please note that the physiological activity of the ingredient(s) described herein is supported by the referenced clinical trial reports. Marketers of finished products containing the ingredient(s) described herein are responsible for determining whether claims made for such products are lawful and in compliance with the laws of the country in which they will market the products.



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Thymocid®, a standardized black cumin (Nigella sativa) seed extract, modulates collagen cross-linking, collagenase and elastase activities, and melanogenesis in murine B16F10 cells.

Huifang Li et al.
Nutrients. 2020 Jul 19. 12(2146): 16pgs. doi: 10.3390/nu12072146
Thymocid® decreased melanin content up to 62% and reduced cellular tyrosinase activity by 21% (at 20 µg/mL) indicating skin brightening potential. It also reduced collagen destruction and thus supports collagen turnover by inhibiting the formation of advanced glycation end-products (AGEs), collagen cross-linking and collagenase enzyme activity.

Anti-melanogenic potential of thymoquinone isolated from black cumin (Nigella sativa L) [as Thymocid®] seed oil.

DaSilva N et al.
University of Rhode Island: INBRE Poster Presentation. 2017.
Tyrosinase and tyrosinase-related protein-1 (TRP-1) and TRP-2 plays a major role in melanin synthesis. Supports youthful skin by inhibiting Tyrosinase and melanin production to look skin tone more even. In an in vitro study, TQ’s de-pigmenting ability against B16F10 melanoma cells was not caused by direct inhibition of the tyrosinase enzyme, but by inhibition of tyrosinase processing and maturation in the melanoma cells. This effect is associated with TQ’s ability to down regulate gene and protein expressions of MITF, TYRP-1 and TYRP-2.

Effects of Nigella sativa oil with a low-calorie diet on cardiometabolic risk factors in obese women: A randomized controlled clinical trial.

Mahdavi R et al.
Food Funct. 2015. 6(6): 2041-2048.
Obese women received a low-calorie diet with Nigella sativa (NS) and it was found that in the NS group, weight, weight circumference, triglycerides, and very low density lipoprotein levels all decreased significantly compared to the placebo group. Weight even decreased by 6%, and waist circumference by 6.9%.

Phytochemistry, pharmacology, and therapeutic uses of black seed (Nigella sativa).

Kooti W et al.
Chinese J Nat Med. 2016. 14(10): 0732-0745. doi: 10.1016/S1875-5364(16)30088-7

Oxidative stress responses to Nigella sativa oil concurrent with a low-calorie diet in obese women: A randomized, double-blind controlled trial.

Namazi N et al.
Phytother Res. 29(11): 1722-1728.
Obese women received a low-calorie diet with Nigella sativa (NS) oil (3 g/day) or a placebo for 8 weeks. Results showed that the NS oil concurrent with a low calorie diet decreased weight (-4.80 +/- 1.50 kg) and increased SOD in obese women compared to placebo.

Indazole-Type alkaloids from Nigella sativa seeds exhibit antihyperglycemic effects via AMPK activation in vitro.

Yuan T et al.
J Nat Prod. 2014 Oct 09. 77(10): 2316-2320. doi: 10.1021/np500398m
A naturally occurring alkaloid from the N. sativa seed increased glucose consumption by liver hepatocytes through activation of AMP-activated protein kinase (AMPK). This is also the first report of 4-O-methylnigellidine and 4-O-methylnigeglanine from a natural source.

Blood pressure lowering effect of Nigella sativa L. seed oil in healthy volunteers: A randomized, double-blind, placebo-controlled clinical trial.

Fallah HH et al.
Phytother Res. 2013. 27(12): 1849-1853. doi: 10.1002/ptr.4944
A randomized, double-blind, placebo controlled trial (n=70) found Nigella oil improved blood pressure.