Bitter melon extract attenuating hepatic steatosis may be mediated by FGF21 adn AMPK/Sirt1 signaling in mice.
Yu Y et al.
Sci Rep. 2013 Nov 05. 3(3142): 1-8.
A murine model examining Factor 21™ showed significant reductions in body weight, fasting plasma glucose, insulin, and FGF21 concentration as well as liver FGF21 and TG content in mice fed a high fat diet. Researchers pose that Factor 21™ supplementation may contribute to either increased energy, reduced caloric absorption from the gut, or a combination of both.