Effect of herbal combination in low bone mass density patients.
Dhatrak S et al.
Int J Drug Discov Technol. 2011. 2(1): 9-14.
In this double blind, randomized, placebo control trial in women (45-60 years old) with low BMD identified by DEXA scan (n=30), supplementation of an herbal combination containing Calzbone® showed significant improvement in bone density parameters namely BMD, T score, and Z score, while also showing a reduction in serum total ALP activity (most commonly used biochemical markers to assess bone turnover (formation and resorption)) in the active treatment group compared to placebo. During the six-month period of this study, BMD was found to increase by 2.74 % in the Calzbone® group.