Longvida® Confirmed To Cross Blood Brain & Blood Retinal Barriers
Longvida® Confirmed To Cross Blood Brain & Blood Retinal Barriers
A recent clinical publication in a peer-reviewed journal, JCI Insight, offers a practical, noninvasive approach to detect and monitor discrete retinal amyloid deposits in patients using solid-lipid curcumin and a modified scanning laser ophthalmoscope.
The researchers conclude that the concept may lead to a practical and feasible approach for large-scale AD diagnosis and monitoring.2
The researchers present an extensive amount of quantitative and histological reports including comparative curcumin data (water soluble, 95% curcuminoids, Longvida®) pharmacokinetic information, dose and regimen calibration, as well as human clinical data.2
In one retinal imaging proof-of-concept report (n = 16), Longvida Optimized Curcumin® was administered orally in healthy and AD subjects. Fundus images showed increased fluorescent intensity in retinal deposits at days 1 and 10 compared to baseline. The researchers found that the Longvida oral curcumin formulation consistently co-labeled Aβ plaques.2
Further, pharmacokinetic analysis in six subjects on a 10-day regimen of Longvida Optimized Curcumin® indicated a significant increase in curcumin levels in both free plasma and red blood cells (see Figure E).2
Tissue curcumin levels in red blood cells (RBCs) and free curcumin in plasma peaked at day 10 (P < 0.0001). The results of free curcumin analysis in plasma and RBCs at day 30 (washout) confirms previous reports of extended transfer of Longvida’s curcumin into the bloodstream and other target tissues1. “The high bioavailability of optimized curcumin was established by increased tissue absorption of free rather than glucuronidated or other curcumin metabolites from the gastrointestinal system to the blood stream.”2
Supplemental data compared three commercially available curcumins for their absorption into the brain and red blood cells, resulting in the highest brain concentrations of free curcumin obtained with Longvida Optimized Curcumin® (see Figure 4B).2
“We are extremely honored to have Longvida® included in this ground breaking trial by such an accomplished group of research experts,” says Kristen Marshall, Marketing Coordinator at Verdure Sciences. “Not only is this an incredible trial, but the publication is incredibly extensive and includes such an immense wealth of information and data that is unlike any other publication to include Longvida. Further, the potential implications of this proof-of-concept trial are profound and very exciting to be a part of.”***
***These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.***
About Longvida®: Patented Longvida Optimized Curcumin® was developed by Verdure Sciences® in collaboration with UCLA neuroscientists with over ten years of bioavailability, efficacy, and safety testing. Longvida’s SLP™ Technology is able to reach target tissues offering efficacious levels of free curcumin at a low daily dose. Longvida® (US Patent 9192644, EP Patent 19933665; additional patents pending) is a registered trademark of Verdure Sciences®, Inc. SLP™ and SLCP™ are trademarks of Verdure® Sciences, Inc.
References:
- Gota VS et al. Safety and pharmacokinetics of a solid lipid curcumin particle formulation. J Agric Food Chem. 2010. 58(4): 2095-99.
- Koronyo Y et al. Retinal amyloid pathology and proof-of-concept imaging trial. JCI Insight. 2017. 2(16).
A recent clinical publication in a peer-reviewed journal, JCI Insight, offers a practical, noninvasive approach to detect and monitor discrete retinal amyloid deposits in patients using solid-lipid curcumin and a modified scanning laser ophthalmoscope.
The researchers conclude that the concept may lead to a practical and feasible approach for large-scale AD diagnosis and monitoring.2
The researchers present an extensive amount of quantitative and histological reports including comparative curcumin data (water soluble, 95% curcuminoids, Longvida®) pharmacokinetic information, dose and regimen calibration, as well as human clinical data.2
In one retinal imaging proof-of-concept report (n = 16), Longvida Optimized Curcumin® was administered orally in healthy and AD subjects. Fundus images showed increased fluorescent intensity in retinal deposits at days 1 and 10 compared to baseline. The researchers found that the Longvida oral curcumin formulation consistently co-labeled Aβ plaques.2
Further, pharmacokinetic analysis in six subjects on a 10-day regimen of Longvida Optimized Curcumin® indicated a significant increase in curcumin levels in both free plasma and red blood cells (see Figure E).2
Tissue curcumin levels in red blood cells (RBCs) and free curcumin in plasma peaked at day 10 (P < 0.0001). The results of free curcumin analysis in plasma and RBCs at day 30 (washout) confirms previous reports of extended transfer of Longvida’s curcumin into the bloodstream and other target tissues1. “The high bioavailability of optimized curcumin was established by increased tissue absorption of free rather than glucuronidated or other curcumin metabolites from the gastrointestinal system to the blood stream.”2
Supplemental data compared three commercially available curcumins for their absorption into the brain and red blood cells, resulting in the highest brain concentrations of free curcumin obtained with Longvida Optimized Curcumin® (see Figure 4B).2
“We are extremely honored to have Longvida® included in this ground breaking trial by such an accomplished group of research experts,” says Kristen Marshall, Marketing Coordinator at Verdure Sciences. “Not only is this an incredible trial, but the publication is incredibly extensive and includes such an immense wealth of information and data that is unlike any other publication to include Longvida. Further, the potential implications of this proof-of-concept trial are profound and very exciting to be a part of.”***
***These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.***
About Longvida®: Patented Longvida Optimized Curcumin® was developed by Verdure Sciences® in collaboration with UCLA neuroscientists with over ten years of bioavailability, efficacy, and safety testing. Longvida’s SLP™ Technology is able to reach target tissues offering efficacious levels of free curcumin at a low daily dose. Longvida® (US Patent 9192644, EP Patent 19933665; additional patents pending) is a registered trademark of Verdure Sciences®, Inc. SLP™ and SLCP™ are trademarks of Verdure® Sciences, Inc.
References:
- Gota VS et al. Safety and pharmacokinetics of a solid lipid curcumin particle formulation. J Agric Food Chem. 2010. 58(4): 2095-99.
- Koronyo Y et al. Retinal amyloid pathology and proof-of-concept imaging trial. JCI Insight. 2017. 2(16).
About Verdure Sciences®:
Verdure Sciences manages ingredient innovation throughout the integration of supply network, production, and research platforms. With an expanding pipeline of proprietary, standardized botanical ingredients supported by pharmacokinetic, pharmacodynamic, and clinical research profiles, we work toward our unified vision to offer safe, effective ingredient solutions. Verdure Sciences® is a registered trademark of Verdure Sciences®, Inc.
For our most current patent and trademark information, please visit: https://vs-corp.com/ip/ | https://vs-corp.com for more information
About Verdure Sciences®:
Verdure Sciences manages ingredient innovation throughout the integration of supply network, production, and research platforms. With an expanding pipeline of proprietary, standardized botanical ingredients supported by pharmacokinetic, pharmacodynamic, and clinical research profiles, we work toward our unified vision to offer safe, effective ingredient solutions. Verdure Sciences® is a registered trademark of Verdure Sciences®, Inc.
For our most current patent and trademark information, please visit: https://vs-corp.com/ip/ | https://vs-corp.com for more information
