Pomella® Research
Pomella® Research
Don’t see what you’re looking for? All additional research is categorized under supportive research.
Prospective Randomized, Double-Blind, Placebo-Controlled Study of a Standardized Oral Pomegranate Extract on the Gut Microbiome and Short-Chain Fatty Acids
Sivamani RK et al.
2023 Dec 19. 13(1): 15pgs. doi: 10.3390/foods13010015
Punica granatum L., commonly known as the pomegranate, is an abundant source of polyphenols, including hydrolyzable ellagitannins, ellagic acid, anthocyanins, and other bioactive phytochemicals shown to be effective in defending against oxidative stress, and has immunomodulatory activities.
Development of a liquid chromatography-tandem mass spectrometry (LC–MS/MS) method for characterizing pomegranate extract pharmacokinetics in humans.
Wang YH et al.
J Pharmaceut Biomed Analysis. 2023 May 31. 233(115477). doi: 10.1016/j.jpba.2023.115477
Recent evidence suggests that gut microbiota-derived urolithin (Uro) metabolites of ellagitannins are pharmacologically active. Studies have evaluated the pharmacokinetics of EA, however, little is known about the disposition of urolithin metabolites (urolithin A (UA) and B (UB)).
Prospective randomized double-blind placebo-controlled study of oral pomegranate extract [as Pomella®] on skin health, skin microbiome, and influence on the gut-skin axis.
Chakkalakal M, Pan A, Nadora D, Gahoonia N, Dumont A, Burney W, Chambers CJ, & Sivamani RK.
Poster presented at the Integrative Dermatology Symposium, September 2022, Tucson, AZ.
Prospective randomized double-blind placebo-controlled study of oral pomegranate extract [Pomella®] on skin wrinkles, biophysical features, and the gut-skin axis.
Chakkalakal M et al.
J Clin Med. 14 Nov 2022. 11(22): 6724. doi: 10.3390/jcm11226724
A prospective, double-blind placebo-controlled study conducted on healthy males and females aged 25-55 years examined Pomella® extract (250mg/day) for its potential to promote skin health benefits, associated influence on the skin-gut axis, and beauty from within. Promising evidence from this clinical trial indicates a statistically significant improvement in multiple markers associated with visible wrinkles and moisture in a healthy population.
Pomegranate (Punica granatum) extract and its polyphenols reduce the formation of methylglyoxal-DNA adducts and protect human keratinocytes against methylglyoxal-induced oxidative stress.
Guo H et al.
J Funct Foods. Aug 2021. 83: 104564. doi: 10.1016/j.jff.2021.104564
Pomegranate extract (PE) and its polyphenols have been reported to show skin protective effects but their cytoprotective effects against methylglyoxal (MGO)-induced DNA damage and cell dysfunctions are unclear. Herein, we evaluated whether PE, punicalagin (PA), ellagic acid (EA), and urolithin A (UA), can alleviate MGO-induced DNA damage in human keratinocytes. PE (50 µg/mL) and PA (50 µM) protected DNA integrity and reduced the formation of MGO-DNA adducts and tailed DNA by 60.2 and 49.7%, respectively, in HaCaT cells.
Screening of Punica granatum extract for antimicrobial activity against oral micro organisms.
Avadhani M et al.
J Ayurvedic Herbal Med. 2020. 6(2): 73-77.
Hepatoprotective and anti-inflammatory effects of a standardized pomegranate (Punica granatum) fruit extract in high fat diet-induced obese C57BL/6 mice.
Pfohl M et al.
Inter J Food Sci Nut. 2020. 1-12.
Ellagic acid source identification by UFLC-PDA-ESI-MS/MS.
Girme A et al.
2019 Oct. Poster presentation in 8th Annual AHPA Botanical Congress.
Development of methodology for analysis of ellagic acid before and after hydrolysis from its prominent source, i.e. Punica granatum. This method has application in confirmation and identification of ellagic acid source identification for confirmation dietary supplement label/s meet stated claim/s for pomegranate extract content.
Biological evaluations of skin protective effects of Pomella® extract on type-I collagen, DNA structure integrity, and human keratinocytes against oxidative and glycative stress.
Ma H et al.
2019 May. Poster presentation in Vitafoods Europe. Geneva, Switzerland.
Pomella® and its phenolics showed protective effects on type-I collagen, DNA structure integrity, and human keratinocytes against H2O2- and MGO-induced oxidative and glycative stress. Punicalagin showed the most promising biological activities among tested pomegranate phenolics. The results suggest that pomegranate phenolics may be utilized as natural antioxidants for various cosmeceutical applications including consumable and topical products for skin health.
Pomegranate phenolics inhibit type I collagen cross-linking induced by glycative stress.
Cai A et al.
FASEB J. 2018 Apr. 32(1): 656.35.
Three of the pomegranate phenolics that Pomella® includes (punicalagin, ellagic acid, and urolithin A) were examined to determine the protective effects on collagen glycation. It was found that the phenolics inhibited fructose-induced collagen glycation by as much as 64.4%, exhibited protective effects on the secondary structure of collagen (when exposed to the denaturing effect of glycation), and inhibited the formation of Amadori products by as much as 45.7%.
Pomegranate (Punica granatum) phenolics ameliorate hydrogen peroxide-induced oxidative stress and cytotoxicity in human keratinocytes.
Liu C et al.
J Funct Foods. 2019. 54: 559-567. doi: 10.1016/j.jff.2019.02.015
Pomella® and its phenolics (punicalagin, ellagic acid, and urolithin A) were investigated in the reduction of oxidative stress and cytotoxicity in keratinocytes and found that the substances reduced the production of hydrogen peroxide induced ROS, increased the viability of the cells, and reduced apoptotic cell populations. This study points to Pomella having potential applications as a natural cosmeceutical for skin health.
Antiproliferative activities of ashwagandha, turmeric, Pomella®, sesamin, and cinnamon extracts against colon and breast cells.
Parang K & Nasrolahi Shirazi A.
Poster presentation in Southern California Conferences for Undergraduate Research. 2019. Poster 4, Location 180.
Liquid chromatography coupled with time-of-flight tandem mass spectrometry for comprehensive phenolic characterization of pomegranate fruit and flower extracts used as ingredients in botanical dietary supplements.
Liu Y et al.
J Sep Sci. 2018 May 30. Vol 41(Issue 15 - August 2018): 3022-3033. doi: 10.1002/jssc.201800480
Pomella® phenolics are comprehensively characterized by a validated liquid chromatography with time-of -flight tandem mass spectrometry method in the highly regarded journal, Journal of Separation Science. This study aids in quality control, authentication of study materials, and standardization of these botanical ingredients to help evaluate their potential health benefits in both completed and on-going pre-clinical and clinical studies.
Development of a neuroprotective potential algorithm for medicinal plants.
Liu W et al.
University of Rhode Island. Neurochem Int. 2016 Sep 29. 100: 164-177.
As part of a strategy to help guide the selection and evaluation of medicinal plant candidates for their neuroprotective potential, researchers at the University of Rhode Island developed a Neuroprotective Potential Algorithm (NPA) by evaluating twenty-three standardized and chemically characterized Ayurvedic medicinal plant extracts in a panel of bioassays targeting oxidative stress, carbonyl stress, protein glycation, amyloid beta (Aβ) fibrillation, acetylcholinesterase (AChE) inhibition, and neuroinflammation.
Antioxidative effect of Punica granatum (pomegranate) on biochemical parameters in patients with T2D and MI: A double blind placebo controlled trial.
Goyal R et al.
Int J Adv Res. 2016 May. Vol 4(Issue 5): 857-864. doi: 10.21474/IJAR01
Patients were administered 300mg of Pomella® twice daily for 30-days as an adjunct treatment and showed significant improvements in key metabolic biomarkers. Especially significant decreases in blood glucose and HbA1c were seen compared to baseline.
Don’t see what you’re looking for? All additional research is categorized under supportive research.
Prospective Randomized, Double-Blind, Placebo-Controlled Study of a Standardized Oral Pomegranate Extract on the Gut Microbiome and Short-Chain Fatty Acids
Sivamani RK et al.
2023 Dec 19. 13(1): 15pgs. doi: 10.3390/foods13010015
Punica granatum L., commonly known as the pomegranate, is an abundant source of polyphenols, including hydrolyzable ellagitannins, ellagic acid, anthocyanins, and other bioactive phytochemicals shown to be effective in defending against oxidative stress, and has immunomodulatory activities.
Development of a liquid chromatography-tandem mass spectrometry (LC–MS/MS) method for characterizing pomegranate extract pharmacokinetics in humans.
Wang YH et al.
J Pharmaceut Biomed Analysis. 2023 May 31. 233(115477). doi: 10.1016/j.jpba.2023.115477
Recent evidence suggests that gut microbiota-derived urolithin (Uro) metabolites of ellagitannins are pharmacologically active. Studies have evaluated the pharmacokinetics of EA, however, little is known about the disposition of urolithin metabolites (urolithin A (UA) and B (UB)).
Prospective randomized double-blind placebo-controlled study of oral pomegranate extract [as Pomella®] on skin health, skin microbiome, and influence on the gut-skin axis.
Chakkalakal M, Pan A, Nadora D, Gahoonia N, Dumont A, Burney W, Chambers CJ, & Sivamani RK.
Poster presented at the Integrative Dermatology Symposium, September 2022, Tucson, AZ.
Prospective randomized double-blind placebo-controlled study of oral pomegranate extract [Pomella®] on skin wrinkles, biophysical features, and the gut-skin axis.
Chakkalakal M et al.
J Clin Med. 14 Nov 2022. 11(22): 6724. doi: 10.3390/jcm11226724
A prospective, double-blind placebo-controlled study conducted on healthy males and females aged 25-55 years examined Pomella® extract (250mg/day) for its potential to promote skin health benefits, associated influence on the skin-gut axis, and beauty from within. Promising evidence from this clinical trial indicates a statistically significant improvement in multiple markers associated with visible wrinkles and moisture in a healthy population.
Pomegranate (Punica granatum) extract and its polyphenols reduce the formation of methylglyoxal-DNA adducts and protect human keratinocytes against methylglyoxal-induced oxidative stress.
Guo H et al.
J Funct Foods. Aug 2021. 83: 104564. doi: 10.1016/j.jff.2021.104564
Pomegranate extract (PE) and its polyphenols have been reported to show skin protective effects but their cytoprotective effects against methylglyoxal (MGO)-induced DNA damage and cell dysfunctions are unclear. Herein, we evaluated whether PE, punicalagin (PA), ellagic acid (EA), and urolithin A (UA), can alleviate MGO-induced DNA damage in human keratinocytes. PE (50 µg/mL) and PA (50 µM) protected DNA integrity and reduced the formation of MGO-DNA adducts and tailed DNA by 60.2 and 49.7%, respectively, in HaCaT cells.
Screening of Punica granatum extract for antimicrobial activity against oral micro organisms.
Avadhani M et al.
J Ayurvedic Herbal Med. 2020. 6(2): 73-77.
Hepatoprotective and anti-inflammatory effects of a standardized pomegranate (Punica granatum) fruit extract in high fat diet-induced obese C57BL/6 mice.
Pfohl M et al.
Inter J Food Sci Nut. 2020. 1-12.
Ellagic acid source identification by UFLC-PDA-ESI-MS/MS.
Girme A et al.
2019 Oct. Poster presentation in 8th Annual AHPA Botanical Congress.
Development of methodology for analysis of ellagic acid before and after hydrolysis from its prominent source, i.e. Punica granatum. This method has application in confirmation and identification of ellagic acid source identification for confirmation dietary supplement label/s meet stated claim/s for pomegranate extract content.
Biological evaluations of skin protective effects of Pomella® extract on type-I collagen, DNA structure integrity, and human keratinocytes against oxidative and glycative stress.
Ma H et al.
2019 May. Poster presentation in Vitafoods Europe. Geneva, Switzerland.
Pomella® and its phenolics showed protective effects on type-I collagen, DNA structure integrity, and human keratinocytes against H2O2- and MGO-induced oxidative and glycative stress. Punicalagin showed the most promising biological activities among tested pomegranate phenolics. The results suggest that pomegranate phenolics may be utilized as natural antioxidants for various cosmeceutical applications including consumable and topical products for skin health.
Pomegranate phenolics inhibit type I collagen cross-linking induced by glycative stress.
Cai A et al.
FASEB J. 2018 Apr. 32(1): 656.35.
Three of the pomegranate phenolics that Pomella® includes (punicalagin, ellagic acid, and urolithin A) were examined to determine the protective effects on collagen glycation. It was found that the phenolics inhibited fructose-induced collagen glycation by as much as 64.4%, exhibited protective effects on the secondary structure of collagen (when exposed to the denaturing effect of glycation), and inhibited the formation of Amadori products by as much as 45.7%.
Pomegranate (Punica granatum) phenolics ameliorate hydrogen peroxide-induced oxidative stress and cytotoxicity in human keratinocytes.
Liu C et al.
J Funct Foods. 2019. 54: 559-567. doi: 10.1016/j.jff.2019.02.015
Pomella® and its phenolics (punicalagin, ellagic acid, and urolithin A) were investigated in the reduction of oxidative stress and cytotoxicity in keratinocytes and found that the substances reduced the production of hydrogen peroxide induced ROS, increased the viability of the cells, and reduced apoptotic cell populations. This study points to Pomella having potential applications as a natural cosmeceutical for skin health.
Antiproliferative activities of ashwagandha, turmeric, Pomella®, sesamin, and cinnamon extracts against colon and breast cells.
Parang K & Nasrolahi Shirazi A.
Poster presentation in Southern California Conferences for Undergraduate Research. 2019. Poster 4, Location 180.
Liquid chromatography coupled with time-of-flight tandem mass spectrometry for comprehensive phenolic characterization of pomegranate fruit and flower extracts used as ingredients in botanical dietary supplements.
Liu Y et al.
J Sep Sci. 2018 May 30. Vol 41(Issue 15 - August 2018): 3022-3033. doi: 10.1002/jssc.201800480
Pomella® phenolics are comprehensively characterized by a validated liquid chromatography with time-of -flight tandem mass spectrometry method in the highly regarded journal, Journal of Separation Science. This study aids in quality control, authentication of study materials, and standardization of these botanical ingredients to help evaluate their potential health benefits in both completed and on-going pre-clinical and clinical studies.
Development of a neuroprotective potential algorithm for medicinal plants.
Liu W et al.
University of Rhode Island. Neurochem Int. 2016 Sep 29. 100: 164-177.
As part of a strategy to help guide the selection and evaluation of medicinal plant candidates for their neuroprotective potential, researchers at the University of Rhode Island developed a Neuroprotective Potential Algorithm (NPA) by evaluating twenty-three standardized and chemically characterized Ayurvedic medicinal plant extracts in a panel of bioassays targeting oxidative stress, carbonyl stress, protein glycation, amyloid beta (Aβ) fibrillation, acetylcholinesterase (AChE) inhibition, and neuroinflammation.
Antioxidative effect of Punica granatum (pomegranate) on biochemical parameters in patients with T2D and MI: A double blind placebo controlled trial.
Goyal R et al.
Int J Adv Res. 2016 May. Vol 4(Issue 5): 857-864. doi: 10.21474/IJAR01
Patients were administered 300mg of Pomella® twice daily for 30-days as an adjunct treatment and showed significant improvements in key metabolic biomarkers. Especially significant decreases in blood glucose and HbA1c were seen compared to baseline.
