Thymocid® Research
Thymocid® Research
Don’t see what you’re looking for? All additional research is categorized under supportive research.
Thymocid®, a standardized black cumin (Nigella sativa) seed extract, modulates collagen cross-linking, collagenase and elastase activities, and melanogenesis in murine B16F10 cells.
Huifang Li et al.
Nutrients. 2020 Jul 19. 12(2146): 16pgs. doi: 10.3390/nu12072146
Thymocid® decreased melanin content up to 62% and reduced cellular tyrosinase activity by 21% (at 20 µg/mL) indicating skin brightening potential. It also reduced collagen destruction and thus supports collagen turnover by inhibiting the formation of advanced glycation end-products (AGEs), collagen cross-linking and collagenase enzyme activity.
Anti-melanogenic potential of thymoquinone isolated from black cumin (Nigella sativa L) [as Thymocid®] seed oil.
DaSilva N et al.
University of Rhode Island: INBRE Poster Presentation. 2017.
Tyrosinase and tyrosinase-related protein-1 (TRP-1) and TRP-2 plays a major role in melanin synthesis. Supports youthful skin by inhibiting Tyrosinase and melanin production to look skin tone more even. In an in vitro study, TQ’s de-pigmenting ability against B16F10 melanoma cells was not caused by direct inhibition of the tyrosinase enzyme, but by inhibition of tyrosinase processing and maturation in the melanoma cells. This effect is associated with TQ’s ability to down regulate gene and protein expressions of MITF, TYRP-1 and TYRP-2.
Effects of Nigella sativa oil with a low-calorie diet on cardiometabolic risk factors in obese women: A randomized controlled clinical trial.
Mahdavi R et al.
Food Funct. 2015. 6(6): 2041-2048.
Obese women received a low-calorie diet with Nigella sativa (NS) and it was found that in the NS group, weight, weight circumference, triglycerides, and very low density lipoprotein levels all decreased significantly compared to the placebo group. Weight even decreased by 6%, and waist circumference by 6.9%.
Phytochemistry, pharmacology, and therapeutic uses of black seed (Nigella sativa).
Kooti W et al.
Chinese J Nat Med. 2016. 14(10): 0732-0745. doi: 10.1016/S1875-5364(16)30088-7
Oxidative stress responses to Nigella sativa oil concurrent with a low-calorie diet in obese women: A randomized, double-blind controlled trial.
Namazi N et al.
Phytother Res. 29(11): 1722-1728.
Obese women received a low-calorie diet with Nigella sativa (NS) oil (3 g/day) or a placebo for 8 weeks. Results showed that the NS oil concurrent with a low calorie diet decreased weight (-4.80 +/- 1.50 kg) and increased SOD in obese women compared to placebo.
Indazole-Type alkaloids from Nigella sativa seeds exhibit antihyperglycemic effects via AMPK activation in vitro.
Yuan T et al.
J Nat Prod. 2014 Oct 09. 77(10): 2316-2320. doi: 10.1021/np500398m
A naturally occurring alkaloid from the N. sativa seed increased glucose consumption by liver hepatocytes through activation of AMP-activated protein kinase (AMPK). This is also the first report of 4-O-methylnigellidine and 4-O-methylnigeglanine from a natural source.
Blood pressure lowering effect of Nigella sativa L. seed oil in healthy volunteers: A randomized, double-blind, placebo-controlled clinical trial.
Fallah HH et al.
Phytother Res. 2013. 27(12): 1849-1853. doi: 10.1002/ptr.4944
A randomized, double-blind, placebo controlled trial (n=70) found Nigella oil improved blood pressure.
Clinical evaluation of Nigella sativa seeds for the treatment of hyperlipidemia: A randomized, placebo controlled clinical trial.
Sabzghabaee AM et al.
Med Arch. 05 May 2012. 66(3): 198-200. doi: 10.5455/medarh.2012.66.198-200
Patients in the study group took 2 grams of N. sativa per day for 4 weeks. A significant decrease in total cholesterol, low density lipoprotein, and triglyceride levels was seen, and it was concluded that N. sativa may have some beneficial effects in promoting healthy blood lipid levels.
Effectiveness of Nigella sativa oil in the management of patients: A placebo controlled study.
Gheita TA et al.
Phytother Res. 2012. 26(8): 1246-1248. doi: 10.1002/ptr.3679
Female patients took a placebo for a month and then NS oil for the month after, 1 gram a day. The activity scores significantly decreased compared with before and after NS oil supplementation, as well as the number of swollen joints and the duration of morning stiffness.
Herbal treatment of allergic rhinitis: The use of Nigella sativa.
Nikakhlagh S et al.
Am J Otolaryngol. 2011. 32(5): 402-407. doi: 10.1016/j.amjoto.2010.07.019
A placebo-controlled study (n = 66) found that N. sativa should be considered for treating allergic rhinitis as a viable alternative to current medication.
Blood glucose lowering effects of Nigella sativa L seeds oil in healthy human volunteers: A randomized, double-bind, placebo-controlled clinical trial.
Mohtashami R et al.
J Med Plants. 2011. 3(39): 90-94.
70 healthy subjects were split into two groups; the study group took 5mL of Nigella sativa oil per day and the control group took 5mL mineral oil per day, both for two months. It was concluded that the administration of NS oil in this way resulted in beneficial effects on glycemic profile (fasting blood glucose, HbA1c, liver and renal function) without any adverse effects.
Efficacy of Nigella sativa on serum free testosterone and metabolic disturbances in central obese male.
Datau EA et al.
Acta Med Indones. 2010 Jul. 42(3). 130-134.
A double blind, randomized, placebo-controlled study with obese males (aged 30 – 45 years) found that there was a significant reduction in body weight, waist circumference, and systolic blood pressure in the treatment group. Nigella sativa was also found to possibly inhibit the decreasing of serum free testosterone.
Effect of Nigella sativa oil on various clinical and biochemical parameters of insulin resistance syndrome.
Namji A et al.
Int J Diab Dev Ctries. 2008 Jan-Mar. 28(1): 11-14. doi: 10.4103/0973-3930.41980
A prospective study testing the effect of N. sativa oil as an add-on therapy in patients of insulin resistance syndrome. Indeed, the oil was found to have significant improvement in total cholesterol, low density lipoprotein cholesterol, and fasting blood glucose.
Immunomodulatory and therapeutic properties of the Nigella sativa L seed.
Salem ML.
Int Immunopharmacol. 2005. 5(13): 1749-1770. doi: 10.1016/j.intimp.2005.06.008
A review that focuses on both Nigella (NS) oil and thymoquinone (TQ); Discusses the various effects and properties that NS oil and TQ possess.
Effect of Nigella sativa (black seed) on subjective feeling in patients with allergic diseases.
Kalus U et al.
Phytother Res. 26 Feb 2003. 17: 1209-1214. doi: 10.1002/ptr.1356
Don’t see what you’re looking for? All additional research is categorized under supportive research.
Thymocid®, a standardized black cumin (Nigella sativa) seed extract, modulates collagen cross-linking, collagenase and elastase activities, and melanogenesis in murine B16F10 cells.
Huifang Li et al.
Nutrients. 2020 Jul 19. 12(2146): 16pgs. doi: 10.3390/nu12072146
Thymocid® decreased melanin content up to 62% and reduced cellular tyrosinase activity by 21% (at 20 µg/mL) indicating skin brightening potential. It also reduced collagen destruction and thus supports collagen turnover by inhibiting the formation of advanced glycation end-products (AGEs), collagen cross-linking and collagenase enzyme activity.
Anti-melanogenic potential of thymoquinone isolated from black cumin (Nigella sativa L) [as Thymocid®] seed oil.
DaSilva N et al.
University of Rhode Island: INBRE Poster Presentation. 2017.
Tyrosinase and tyrosinase-related protein-1 (TRP-1) and TRP-2 plays a major role in melanin synthesis. Supports youthful skin by inhibiting Tyrosinase and melanin production to look skin tone more even. In an in vitro study, TQ’s de-pigmenting ability against B16F10 melanoma cells was not caused by direct inhibition of the tyrosinase enzyme, but by inhibition of tyrosinase processing and maturation in the melanoma cells. This effect is associated with TQ’s ability to down regulate gene and protein expressions of MITF, TYRP-1 and TYRP-2.
Effects of Nigella sativa oil with a low-calorie diet on cardiometabolic risk factors in obese women: A randomized controlled clinical trial.
Mahdavi R et al.
Food Funct. 2015. 6(6): 2041-2048.
Obese women received a low-calorie diet with Nigella sativa (NS) and it was found that in the NS group, weight, weight circumference, triglycerides, and very low density lipoprotein levels all decreased significantly compared to the placebo group. Weight even decreased by 6%, and waist circumference by 6.9%.
Phytochemistry, pharmacology, and therapeutic uses of black seed (Nigella sativa).
Kooti W et al.
Chinese J Nat Med. 2016. 14(10): 0732-0745. doi: 10.1016/S1875-5364(16)30088-7
Oxidative stress responses to Nigella sativa oil concurrent with a low-calorie diet in obese women: A randomized, double-blind controlled trial.
Namazi N et al.
Phytother Res. 29(11): 1722-1728.
Obese women received a low-calorie diet with Nigella sativa (NS) oil (3 g/day) or a placebo for 8 weeks. Results showed that the NS oil concurrent with a low calorie diet decreased weight (-4.80 +/- 1.50 kg) and increased SOD in obese women compared to placebo.
Indazole-Type alkaloids from Nigella sativa seeds exhibit antihyperglycemic effects via AMPK activation in vitro.
Yuan T et al.
J Nat Prod. 2014 Oct 09. 77(10): 2316-2320. doi: 10.1021/np500398m
A naturally occurring alkaloid from the N. sativa seed increased glucose consumption by liver hepatocytes through activation of AMP-activated protein kinase (AMPK). This is also the first report of 4-O-methylnigellidine and 4-O-methylnigeglanine from a natural source.
Blood pressure lowering effect of Nigella sativa L. seed oil in healthy volunteers: A randomized, double-blind, placebo-controlled clinical trial.
Fallah HH et al.
Phytother Res. 2013. 27(12): 1849-1853. doi: 10.1002/ptr.4944
A randomized, double-blind, placebo controlled trial (n=70) found Nigella oil improved blood pressure.
Clinical evaluation of Nigella sativa seeds for the treatment of hyperlipidemia: A randomized, placebo controlled clinical trial.
Sabzghabaee AM et al.
Med Arch. 05 May 2012. 66(3): 198-200. doi: 10.5455/medarh.2012.66.198-200
Patients in the study group took 2 grams of N. sativa per day for 4 weeks. A significant decrease in total cholesterol, low density lipoprotein, and triglyceride levels was seen, and it was concluded that N. sativa may have some beneficial effects in promoting healthy blood lipid levels.
Effectiveness of Nigella sativa oil in the management of patients: A placebo controlled study.
Gheita TA et al.
Phytother Res. 2012. 26(8): 1246-1248. doi: 10.1002/ptr.3679
Female patients took a placebo for a month and then NS oil for the month after, 1 gram a day. The activity scores significantly decreased compared with before and after NS oil supplementation, as well as the number of swollen joints and the duration of morning stiffness.
Herbal treatment of allergic rhinitis: The use of Nigella sativa.
Nikakhlagh S et al.
Am J Otolaryngol. 2011. 32(5): 402-407. doi: 10.1016/j.amjoto.2010.07.019
A placebo-controlled study (n = 66) found that N. sativa should be considered for treating allergic rhinitis as a viable alternative to current medication.
Blood glucose lowering effects of Nigella sativa L seeds oil in healthy human volunteers: A randomized, double-bind, placebo-controlled clinical trial.
Mohtashami R et al.
J Med Plants. 2011. 3(39): 90-94.
70 healthy subjects were split into two groups; the study group took 5mL of Nigella sativa oil per day and the control group took 5mL mineral oil per day, both for two months. It was concluded that the administration of NS oil in this way resulted in beneficial effects on glycemic profile (fasting blood glucose, HbA1c, liver and renal function) without any adverse effects.
Efficacy of Nigella sativa on serum free testosterone and metabolic disturbances in central obese male.
Datau EA et al.
Acta Med Indones. 2010 Jul. 42(3). 130-134.
A double blind, randomized, placebo-controlled study with obese males (aged 30 – 45 years) found that there was a significant reduction in body weight, waist circumference, and systolic blood pressure in the treatment group. Nigella sativa was also found to possibly inhibit the decreasing of serum free testosterone.
Effect of Nigella sativa oil on various clinical and biochemical parameters of insulin resistance syndrome.
Namji A et al.
Int J Diab Dev Ctries. 2008 Jan-Mar. 28(1): 11-14. doi: 10.4103/0973-3930.41980
A prospective study testing the effect of N. sativa oil as an add-on therapy in patients of insulin resistance syndrome. Indeed, the oil was found to have significant improvement in total cholesterol, low density lipoprotein cholesterol, and fasting blood glucose.
Immunomodulatory and therapeutic properties of the Nigella sativa L seed.
Salem ML.
Int Immunopharmacol. 2005. 5(13): 1749-1770. doi: 10.1016/j.intimp.2005.06.008
A review that focuses on both Nigella (NS) oil and thymoquinone (TQ); Discusses the various effects and properties that NS oil and TQ possess.
Effect of Nigella sativa (black seed) on subjective feeling in patients with allergic diseases.
Kalus U et al.
Phytother Res. 26 Feb 2003. 17: 1209-1214. doi: 10.1002/ptr.1356
