These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

Please note that the physiological activity of the ingredient(s) described herein is supported by the referenced clinical trial reports. Marketers of finished products containing the ingredient(s) described herein are responsible for determining whether claims made for such products are lawful and in compliance with the laws of the country in which they will market the products.



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Effects of a Bacopa monnieri extract (Bacognize®) on stress, fatigue, quality of life and sleep in adults with self-reported poor sleep: A randomised, double-blind, placebo-controlled study.

Lopresti AL et al.
J Funct Foods. Oct 2021. 85: 104671. Epub 05 Aug 2021. doi: 10.1016/j.jff.2021.104671
Researchers examined the ability of Bacognize® to act as an adaptogen. Quality of life (QOL) measures were taken as well as salivary biomarkers. The results showed an overall improvement in the Bacognize® group when compared to placebo in all QOL measures (alertness upon awakening, emotional wellbeing, general health and pain), with positive changes in PM melatonin, decrease in CRP, and trending increase of morning cortisol levels. Overall, the quality of sleep was better based on the QOL measures, without the product inducing sleepiness or morning grogginess. The ability to improve grogginess was significant.

Acute effects of combined bacopa, American ginseng and whole coffee fruit on working memory and cerebral haemodynamic response of the prefrontal cortex: A double-blind, placebo-controlled study.

Best T et al.
Nutr Neurosci. 2019 Nov 18. 12pgs. doi: 10.1080/1028415X.2019.1690288
This study examined the acute effects on cognitive performance in healthy adults following intake of a combined, multi-ingredient supplement and also examined the effects on the prefrontal cortex. In addition to brain imaging, measures of mood and cognitive performance were assessed. Results of this multi-ingredient study further support those seen in previous studies examining Bacognize®.

Bacopa monnieri (Bacognize®) - Essential compliance to manage supply chain challenges.

Grime A et al.
Poster presentation in 7th Annual AHPA Botanical Congress. 2018 Nov. Las Vegas, NV, USA.
Market demand increases supply chain risk and without systematic supply chain criteria, several quality issues may arise. Multiple control points through a standardized supply chain regimen aim to offer quality assurance and control of a traditional Ayurvedic botanical commonly known to have supply chain concerns.

Development of a neuroprotective potential algorithm for medicinal plants.

Liu W et al.
University of Rhode Island. Neurochem Int. 2016 Sep 29. 100: 164-177.
As part of a strategy to help guide the selection and evaluation of medicinal plant candidates for their neuroprotective potential, researchers at the University of Rhode Island developed a Neuroprotective Potential Algorithm (NPA) by evaluating twenty-three standardized and chemically characterized Ayurvedic medicinal plant extracts in a panel of bioassays targeting oxidative stress, carbonyl stress, protein glycation, amyloid beta (Aβ) fibrillation, acetylcholinesterase (AChE) inhibition, and neuroinflammation. Bacognize showed the highest in anti-Aβ fibrillation in both methods.

Efficacy of standardized extract of Bacopa monnieri (Bacognize®) on cognitive functions of medical students: A six-week, randomized placebo-controlled trial.

Kumar et al.
Evidence-Based Comp Alter Med. 2016 Sep 15. Vol 2016 (Art ID 4103423): 8pgs. doi: 10.1155/2016/4103423
In a randomized, placebo-controlled crossover human clinical trial, administration of Bacognize® at 300mg/day to healthy medical students significantly improved (p<0.05) several parameters of cognitive function, including memory, focus, and attention. No adverse events were reported in either the Bacognize® or placebo groups.

Effects of Bacopa monnieri (Bacognize®) on memory and cognitive function in healthy older adults: A double-blind placebo-controlled study.

Headapohl et al.
2012 Unpublished manuscript, pending poster presentation/publication.
In a randomized, placebo-controlled trial in older adults, positive trends in working memory, attention, and focus were seen in the Bacognize® group (300mg/day) compared to placebo. Further, no adverse events were reported in either the Bacognize or placebo groups.